Sökning: "USP17"
Hittade 3 avhandlingar innehållade ordet USP17.
1. Mechanisms of modulation of PDGFRβ signaling
Sammanfattning : Platelet-derived growth factors (PDGF) constitute a family of five functional dimers that bind to two structurally related tyrosine kinase receptors i.e. PDGF receptor α and β (PDGFRα and PDGFRβ, respectively), controlling cell growth, proliferation, and migration in cells of mesenchymal origin. LÄS MER
2. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer
Sammanfattning : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. LÄS MER
3. Modulation of PDGF receptors function by posttranslational modifications
Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER