Sökning: "Cadherin"

Visar resultat 1 - 5 av 91 avhandlingar innehållade ordet Cadherin.

  1. 1. Regulation of E-cadherin mediated adhesion in thyroid epithelial cells

    Författare :Fredrik Larsson; Göteborgs universitet; []
    Nyckelord :thyroid; adherens junction; E-cadherin; thyrotropin; cAMP; PKA; Epac; IQGAP;

    Sammanfattning : Cell adhesion is one of multicellular organisms most fundamental features. Cells connect to each other by transmembrane proteins arranged in junction complexes. LÄS MER

  3. 2. Classical cadherins and the thyroid. Studies on organ development and epithelial differentiation

    Författare :Mats Grände; Göteborgs universitet; []
    Nyckelord :Thyroid; cadherin; TGF-; EGF; MEK; development; EMT;

    Sammanfattning : The cadherins are key regulators of tissue patterning and organ formation. E-cadherin is important for cell-cell adhesion and promotes epithelial morphogenesis and maintenance of the epithelial phenotype. LÄS MER

  4. 3. The beneficial Effects of Neural Crest Stem Cells on Pancreatic      β–cells

    Författare :Anongnad Ngamjariyawat; Elena Kozlova; Leif Jansson; Jens Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural Crest Stem Cells; Pancreatic Islets; β-cell proliferation; β-cell survival; Cadherin; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Patients with type-1 diabetes lose their β-cells after autoimmune attack. Islet transplantation is a co-option for curing this disease, but survival of transplanted islets is poor. Thus, methods to enhance β-cell viability and function as well as methods to expand β-cell mass are required. LÄS MER

  5. 4. Regulatory Effects of TGF-β Superfamily Members on Normal and Neoplastic Thyroid Epithelial Cells

    Författare :Åsa Franzén; Paschalis Sideras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; activin; BMP; cadherin; carcinoma; cell cycle arrest; dedifferentiation; EGF; growth inhibition; invasion; Smad; TGF-β; thyroid; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Thyroid growth and function is partly regulated by growth factors binding to receptors on the cell surface. In the present thesis, the transforming growth factor-β (TGF-β) superfamily members have been studied for their role in regulation of growth and differentiation of both normal and neoplastic thyroid epithelial cells. LÄS MER

  7. 5. Molecular factors influencing epithelial-mesenchymal transition in breast cancer

    Författare :Gisela M A Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; epithelial-mesenchymal transition; c-erbB2; E-cadherin; NFI-C2; FoxF1; LOX;

    Sammanfattning : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. LÄS MER