Sökning: "epithelial-mesenchymal transition"
Visar resultat 1 - 5 av 40 avhandlingar innehållade orden epithelial-mesenchymal transition.
1. Molecular factors influencing epithelial-mesenchymal transition in breast cancer
Sammanfattning : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. LÄS MER
2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition
Sammanfattning : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. LÄS MER
3. Oral lichen planus : studies of factors involved in differentiation, epithelial mesenchymal transition and inflammation
Sammanfattning : Background: Lichen planus is a chronic inflammation of skin and mucosa with unknown cause. Oral Lichen Planus, OLP, affects around 2% of the population. Autoimmunity has been suggested as a possible cause as the disease has autoimmune features such as female predominance, cyclic nature and cytotoxic T-cell infiltrate. LÄS MER
4. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis
Sammanfattning : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. LÄS MER
5. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors
Sammanfattning : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. LÄS MER