Sökning: "CAR T-cell therapy"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden CAR T-cell therapy.

1. 6. Cancer imaging and image analysis methods in whole-body MRI and PET/MRI

   Författare :Therese Sjöholm; Joel Kullberg; Filip Malmberg; Robin Strand; Håkan Ahlström; Einar Heiberg Brandt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; magnetic resonance imaging; diffusion weighted imaging; positron emission tomography; whole-body imaging; normal atlas; CAR T-cell therapy; lymphoma; medical image analysis; Computerized Image Processing; Datoriserad bildbehandling;

   Sammanfattning : Diagnostic medical imaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) can provide structural and functional assessments of the whole body. This has great value for potentially systemic diseases such as cancer. LÄS MER

3. 7. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials

   Författare :Elin Forsberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; uveal melanoma; patient-derived xenograft; immune-humanized mouse model; immunotherapy; adoptive T cell therapy; tumor-infiltrating lymphocytes; chimeric antigen receptor T CAR-T cells;

   Sammanfattning : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. LÄS MER

4. 8. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

   Författare :Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

   Sammanfattning : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. LÄS MER

5. 9. Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer

   Författare :Esther Schoutrop; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR T cells and remarkable clinical response rates have been achieved with second generation CD19-directed CAR T cells containing either a CD28 or 4-1BB co-stimulatory domain for the treatment of B cell malignancies. LÄS MER

7. 10. Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation

   Författare :Stefanie Marie Renken; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of patients does not benefit from this treatment. LÄS MER