Sökning: "Esther Schoutrop"

Hittade 1 avhandling innehållade orden Esther Schoutrop.

1. 1. Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer

   Författare :Esther Schoutrop; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR T cells and remarkable clinical response rates have been achieved with second generation CD19-directed CAR T cells containing either a CD28 or 4-1BB co-stimulatory domain for the treatment of B cell malignancies. LÄS MER