Sökning: "Biochemistry towards Bioinformatics"

Visar resultat 21 - 25 av 41 avhandlingar innehållade orden Biochemistry towards Bioinformatics.

1. 21. Network and gene expression analyses for understanding protein function

   Författare :Oliver Frings; Erik Sonnhammer; Rune Linding; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; network inference; network analysis; clustering; network module; network crosstalk; expression analysis; gene signature; biomarker; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Biological function is the result of a complex network of functional associations between genes or their products. Modeling the dynamics underlying biological networks is one of the big challenges in bioinformatics. LÄS MER

3. 22. Bioinformatics Methods for Topology Prediction of Membrane Proteins

   Författare :Konstantinos Tsirigos; Arne Elofsson; Mauno Vihinen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Membrane proteins are key elements of the cell since they are associated with a variety of very important biological functions crucial to its survival. They are implicated in cellular recognition and adhesion, act as molecular receptors, transport substrates through membranes and exhibit specific enzymatic activity. LÄS MER

4. 23. Protein Model Quality Assessment : A Machine Learning Approach

   Författare :Karolis Uziela; Arne Elofsson; Liam McGuffin; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Model Quality Assessment; structural bioinformatics; machine learning; deep learning; support vector machine; proq; Artificial Neural Network; protein structure prediction; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Many protein structure prediction programs exist and they can efficiently generate a number of protein models of a varying quality. One of the problems is that it is difficult to know which model is the best one for a given target sequence. Selecting the best model is one of the major tasks of Model Quality Assessment Programs (MQAPs). LÄS MER

5. 24. Towards Classification and Functional Description of Enzymes: A case study of feruloyl esterases

   Författare :Gupta Udatha; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; descriptors; enzyme immobilization; catalytic triad; pharmacophore; enzyme promiscuity; functional classification; molecular docking; feruloyl esterases; protein evolution; structure-function relationship;

   Sammanfattning : The prediction of enzyme functionality from sequence or structure data remains a challenging task that can be best addressed by studying the structure-function relationships determined from previously available information. This thesis work was focused on developing a reliable classification and functional description for the feruloyl esterase (FAE) enzyme family, whose members’ possess both structural and catalytic promiscuity. LÄS MER

7. 25. Big data networks and orthology analysis

   Författare :Emma Persson; Erik Sonnhammer; Albert László Barabási; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ortholog; protein domain; functional association network; pathway enrichment analysis; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : Understanding biological systems in complex organisms is important in life science in order to comprehend the interplay of genes, proteins, and compounds causing complex diseases. As biological systems are intricate, bioinformatics tools, models, and algorithms are of the utmost importance to understand the bigger picture and decipher biological meaning from the vast amounts of information available from biological experiments and predictions. LÄS MER