Sökning: "Biochemistry towards Bioinformatics"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden Biochemistry towards Bioinformatics.

  1. 6. Development and Application of Molecular Modeling Methods for Structure-Based Drug Discovery

    Författare :Axel Rudling; Jens Carlsson; Phillip Biggin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Molecular modeling is increasingly being integrated into the drug discovery process. Although computational methods are already an essential part of the process today, these techniques have vast potential to evolve and refine drug design in the future. LÄS MER

  3. 7. Decipher protein complex structures from sequence

    Författare :Wensi Zhu; Arne Elofsson; Nathalie Reuter; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein complex structure prediction; protein interaction; AI; AlphaFold; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : Proteins are essential constituents of biological systems. A profound understanding of protein structure is significant for unraveling the intricate mechanisms of biological processes. The recent development of computational methods using AI technology is revolutionizing the structural biology field. LÄS MER

  4. 8. From Sequence to Structure : Using predicted residue contacts to facilitate template-free protein structure prediction

    Författare :Mirco Michel; Arne Elofsson; Erik Lindahl; Johannes Söding; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein bioinformatics; protein structure prediction; contact prediction; machine learning; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Despite the fundamental role of experimental protein structure determination, computational methods are of essential importance to bridge the ever growing gap between available protein sequence and structure data. Common structure prediction methods rely on experimental data, which is not available for about half of the known protein families. LÄS MER

  5. 9. Orphan Genes Bioinformatics : Identification and properties of de novo created genes

    Författare :Walter Basile; Arne Elofsson; Diethard Tautz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; de novo; orphans; evolutionary genetics; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Even today, many genes are without any known homolog. These "orphans" are found in all species, from Viruses to Prokaryotes and Eukaryotes. For a portion of these genes, we might simply not have enough data to find homologs yet. LÄS MER

  7. 10. Engineering enzymes towards biotherapeutic applications using ancestral sequence reconstruction

    Författare :Natalie Hendrikse; Per-Olof Syrén; Johan Rockberg; Erik Nordling; Reinhard Sterner; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzyme engineering; enzyme evolution; ancestral sequence reconstruction; therapeutic enzymes; terpene cyclases; ammonia-lyases; sulfatases; lysosomal enzymes; Kemi; Chemistry;

    Sammanfattning : Enzymes are versatile biocatalysts that fulfill essential functions in all forms of life and, therefore, play an important role in health and disease. One specific application of enzymes in life science is their use as biopharmaceuticals, which typically benefits from high catalytic activity and stability. LÄS MER