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Visar resultat 1 - 5 av 51 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Murine plasmacytomagenesis : an experimental model of B-cell neoplasia

    Författare :Santiago C Silva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mouse plasmacytomas; chromosomal translocation; chimeric mice; MYC-transgenic mice; ;

    Sammanfattning : A chromosomal translocation which results in the illegitimate activation of the c-myc proto-oncogene by one of the three immunoglobulin (Ig) loci is invariably associated with human Burkitt's Lymphoma (BL), mouse plasmacytoma (MPC) and rat immunocytomas (RIC). In the MPC system a genetic predisposition linked to the BALB/c strain has been suggested. LÄS MER

  3. 2. Peripheral Regulation of Pain and Itch

    Författare :Elín Ingibjörg Magnúsdóttir; Malin C. Lagerström; George H. Caughey; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; itch; CGRP; TRPV1; mast cell; mast cell protease; mMCP4; mMCP6; CPA3; endothelin-1; compound 48 80; MRGPRX2; single-stranded oligonucleotide;

    Sammanfattning : Pain and itch are diverse sensory modalities, transmitted by the somatosensory nervous system. Stimuli such as heat, cold, mechanical pain and itch can be transmitted by different neuronal populations, which show considerable overlap with regards to sensory activation. LÄS MER

  4. 3. Mycobacterial infection: Immune evasion, host susceptibility and immunological markers of diagnostic importance

    Författare :John Arko-Mensah; Carmen Fernandez; Francesco Dieli; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mycobacteria; Mice; Toll-like receptors; interferon gamma; immunological markers; lung; respiratory tract; susceptibility; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-γ mediated killing of mycobacteria by murine macrophages in vitro. TLR2, but not TLR4 ligation interfered with IFN-γ mediated killing of mycobacteria in macrophages. LÄS MER

  5. 4. Helicobacter pylori infection in a mouse model: Development, optimization and inhibitory effects of antioxidants

    Författare :Xin Wang; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; virology; bacteriology; Microbiology; mice; Helicobacter pylori; gastritis; lymphoma; antioxidant; diet; Th1 and Th2; cytokines; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Helicobacter pylori is a human pathogen strongly associated with chronic type B gastritis, peptic ulcer disease, gastric cancer and MALT lymphoma. Our aims were to establish a mouse model of H. pylori infection, to study pathogenesis of gastritis and gastric cancer and to investigate new treatment strategies in this model. LÄS MER

  7. 5. Development and validation of a localized murine candidiasis model : The pathogenesis, chemotheraphy and defense mechanisms to Candida mastitis in the lactating mouse

    Författare :Faisal Abdi Guhad; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Murine model; Candida albicans; Pathogenesis; Virulence factors; Amphotericin B; Fluconazole; Complement activation; C3c; SCID mice; Nude mice; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : A murine model of localized candidiasis (mastitis) was developed. The model was analyzed withrespect to its discriminative abilities through investigation of the virulence properties of C.albicans mutant strains compared with the wild-type parental strain. LÄS MER