Sökning: "Adipose Tissue: metabolism"

Visar resultat 1 - 5 av 170 avhandlingar innehållade orden Adipose Tissue: metabolism.

1. 1. Adipose tissue as an active organ : blood flow regulation and tissue-specific glucocorticoid metabolism

   Författare :Jonas Andersson; Tommy Olsson; Stefan Söderberg; Sverker Jern; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11β-hydroxysteroid dehydrogenase type 1; adipose tissue; autonomic nervous system; blood flow; cortisol; nitric oxide; weight loss.; medicin; Medicine;

   Sammanfattning : Background: Despite advances in the treatment of atherosclerosis, cardiovascular disease is the leading cause of death worldwide. With the population getting older and more obese, the burden of cardiovascular disease may further increase. LÄS MER

3. 2. Leptin and the Intersection of Cardiovascular Disease, Metabolism, and Adipose Tissue

   Författare :Camilla Vavruch; Fredrik Nyström; Carl Johan Östgren; Johan Ärnlöv; Kristina Boström; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leptin; Type 2 diabetes mellitus; Adipose tissue; Cardiovascular disease; Metabolism; Cardiovascular risk factors;

   Sammanfattning : According to the World Health Organization, cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels, and it is the leading cause of death worldwide. The risk factors for CVD are divided into two major classes: non-modifiable (age, gender, family history) and modifiable (including tobacco use, type 2 diabetes mellitus (T2DM), physical inactivity, unhealthy diet, abdominal obesity, high cholesterol, dyslipidemia, and stress). LÄS MER

4. 3. Role of caveolin-1 in brown adipose tissue

   Författare :Charlotte L. Mattsson; Barbara Cannon; Paul Pilch; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; caveolin; brown adipose tissue; metabolism; signaling; Physiology; Fysiologi; fysiologi; Physiology;

   Sammanfattning : Caveolae are 50-100 nm invaginations in the plasma membrane. Caveolae and the protein caveolin-1 (Cav1) have been shown to be important in many signaling pathways in different cell types; however, in some cell types caveolae and Cav1 do not seem to affect the investigated signaling pathways. LÄS MER

5. 4. Metabolic and immunological interactions between adipose tissue and breast cancer - implications of obesity in tumor progression

   Författare :Peter Micallef; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Adipose tissue; Macrophage; Metabolism; Paracrine;

   Sammanfattning : Triple-negative breast cancers have fewer treatment options than other breast cancers. The overall goal of this research is to identify new pharmaceutical targets for triple-negative breast cancer through studies of the tumor-promoting crosstalk between tumor and surrounding adipose tissue. LÄS MER

7. 5. Pharmacological and genetic manipulation of adipose cell differentiation and metabolism

   Författare :Milica Vranic; Maria J. Pereira; Jan Eriksson; Niklas Mejhert; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; adipocyte; type 2 diabetes; CRISP Cas9; FKBP51; CDKN2C; second-generation antipsychotics; glucocorticoids; dopamine; dopamine receptor;

   Sammanfattning : Adipose tissue dysfunction has a pivotal role in the development of obesity and related metabolic complications, such as insulin resistance, cardiovascular disease, and diabetes. The overall aim was to study the consequences of adipose exposure to pharmacological agents, as well as dysregulations in the expression of genes, potentially involved in adipose tissue dysfunction and related metabolic impairments. LÄS MER