Sökning: "Activity Diamond"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Activity Diamond.

  1. 1. The Activity Diamond - Modeling an Enhanced Accessibility

    Författare :Per-Olof Hedvall; Bodil Jönsson; Victor Kaptelinin; Certec - Rehabiliteringsteknik och Design; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Activity Diamond; Cultural-historical Activity Theory; Disability; Epiaccessibility; Accessibility; Lived Accessibility; Design; ICF; Social model; Activity Diamond; Cultural-historical Activity Theory; Disability; Epiaccessibility; Accessibility; Lived Accessibility; Design; ICF; Social model;

    Sammanfattning : The purpose of the research presented in this thesis is to enhance the field of accessibility to include a multitude of perspectives. Based on cultural-historical activity theory (CHAT), it analyzes how human, artifactual and natural factors impact an individual’s possibilities to act in concrete situations that are part of a systemic whole. LÄS MER

  3. 2. Ribosomal Proteins in Diamond-Blackfan Anemia : Insights into Failure of Ribosome Function

    Författare :Jitendra Badhai; Niklas Dahl; Anthony Wright; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diamond-Blackfan anemia; RPS19; Ribosomal proteins; Haploinsufficiency; cell cycle; Apoptosis; Erythropoiesis; Medical genetics; Medicinsk genetik; Clinical Genetics; klinisk genetik;

    Sammanfattning : Diamond-Blackfan anemia (DBA) is a severe congenital anemia characterized by a defect in red blood cell production. The disease is associated with growth retardation, malformations, a predisposition for malignant disease and heterozygous mutations in either of the ribosomal protein (RP) genes RPS7, RPS17, RPS19, RPS24, RPL5, RPL11 and RPL35a. LÄS MER

  4. 3. On new and current treatments for Diamond-Blackfan anemia

    Författare :Sara Sjögren; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :Diamond-Blackfan anemia; Erythropoiesis; Ribosome biogenesis; Heme synthesis; Glucocorticoids; p53; Globin translation; HRI; a1-microglobulin;

    Sammanfattning : Diamond-Blackfan anemia (DBA) is a rare congenital disease where the patients suffer from macrocytic anemia due to reduced numbers of erythroid precursors in the bone marrow. Most patients carry mutations in ribosomal proteins, such as ribosomal protein S19 (RPS19), which causes deficient ribosome biogenesis and affects protein translation. LÄS MER

  5. 4. Cell and gene therapy for blood disorders. Modeling of novel treatment strategies for Gaucher type 1 disease and Diamond-Blackfan anemia in mice

    Författare :Maria Dahl; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gaucher disease; lentiviral vectors; gene therapy; Diamond-Blackfan anemia; hematopoietic stem cells; bone marrow transplant; Schlafen-2;

    Sammanfattning : Gaucher disease type 1 (GD type 1) and Diamond-Blackfan anemia (DBA) are rare genetic disorders affecting the hematopoietic system and routinely treated by administration of drugs with variable clinical efficacy. Though effective in alleviating disease symptoms in large cohorts of patients, these treatment options have the major drawback of being non-curative. LÄS MER

  7. 5. Designing guidance along audio-haptically augmented paths in a city environment

    Författare :Delphine Szymczak; Certec - Rehabiliteringsteknik och Design; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Activity theory; Cultural historical; design; evaluation; iterative design; user-centered design; audio-tactile; multimodal; mobile; pedestrian navigation; scanning; tourist guide; vibration; in-use; focus; environment;

    Sammanfattning : The main purpose of this thesis is to show in a case study how it is possible to inform, with Activity Theory, the design and evaluation of a pedestrian navigation system that uses audio-tactile feedback. The case study consists of an iterative design process that results in a tourist guide application used in a mobile phone. LÄS MER