Sökning: "9-Aminoacridine"

Hittade 3 avhandlingar innehållade ordet 9-Aminoacridine.

  1. 1. Synthesis of Organic Compounds for Nuclide Therapy : Derivatives of Carboranes, 9-Aminoacridine and Anthracyclines

    Författare :Senait Ghirmai; Stefan Sjöberg; Vladimir Tolmachev; Tor Kihlberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 9-Aminoacridin; Carborane; Daunorubicin; Doxorubicin; BNCT; Iodine-125; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis addresses the synthesis of organic compounds, some of them are derivatives of compounds with DNA binding properties, for potential use in targeted nuclide therapy. The compounds synthesized therefore also need to contain potent nuclides. LÄS MER

  3. 2. Radiohalogenated Compounds for Tumor Targeting : Synthesis and Radiolabeling

    Författare :Eskender Mume; Stefan Sjöberg; Vladimir Tolmachev; D. Scott Wilbur; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; 9-Aminoacridine; Daunorubicin; Doxorubicin; Carborane; Radiobromination; Radioiodination; Affibody; Monoclonal antibody; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : This thesis describes the synthesis and radiohalogenation of compounds of potential use for tumor targeting. The first section describes the synthesis and radioiodination of DNA intercalating compounds. The compounds are derivatives of 9-aminoacridine, and the anthracyclins daunorubicin and doxorubicin. LÄS MER

  4. 3. Structural Adaptation of DNA to Small Ligands and Recombination Proteins

    Författare :Hye-Kyung Kim; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; triplex DNA; groove binders; intercalators; SANS; DNA; optical spectroscopy; recombination proteins;

    Sammanfattning : In order to contribute to the understanding of mechanisms of recognition in nucleic acid systems, the interaction of DNA with a variety of ligands, representing different cases of adaptation of the double-helix structure, was studied using flow linear dichroism (LD), circular dichroism (CD), fluorescence and absorption spectroscopic techniques. A chiral hydrophobic metal complex, [Ru(dpphen)3]2+ was examined, since this had been reported to be the most efficient molecule to discriminate DNA handedness. LÄS MER