Sökning: "Radioiodination"

Hittade 4 avhandlingar innehållade ordet Radioiodination.

  1. 1. Radiohalogenated Compounds for Tumor Targeting : Synthesis and Radiolabeling

    Författare :Eskender Mume; Stefan Sjöberg; Vladimir Tolmachev; D. Scott Wilbur; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; 9-Aminoacridine; Daunorubicin; Doxorubicin; Carborane; Radiobromination; Radioiodination; Affibody; Monoclonal antibody; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : This thesis describes the synthesis and radiohalogenation of compounds of potential use for tumor targeting. The first section describes the synthesis and radioiodination of DNA intercalating compounds. The compounds are derivatives of 9-aminoacridine, and the anthracyclins daunorubicin and doxorubicin. LÄS MER

  3. 2. Radiohalogenation of biomolecules : An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution

    Författare :Jacek Koziorowski; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging and inradionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. LÄS MER

  4. 3. Synthesis of Organic Compounds for Nuclide Therapy : Derivatives of Carboranes, 9-Aminoacridine and Anthracyclines

    Författare :Senait Ghirmai; Stefan Sjöberg; Vladimir Tolmachev; Tor Kihlberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 9-Aminoacridin; Carborane; Daunorubicin; Doxorubicin; BNCT; Iodine-125; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis addresses the synthesis of organic compounds, some of them are derivatives of compounds with DNA binding properties, for potential use in targeted nuclide therapy. The compounds synthesized therefore also need to contain potent nuclides. LÄS MER

  5. 4. Affibody Molecules for PET Imaging

    Författare :Joanna Strand; Tolmachev Vladimir; Sten Nilsson; Uppsala universitet; []
    Nyckelord :Affibody molecules; Molecular imaging; PET; Radiolabelling; HER2; PDGFRβ; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. LÄS MER