Sökning: "wild-type"

Visar resultat 26 - 30 av 1022 avhandlingar innehållade ordet wild-type.

  1. 26. Directed Enzyme Evolution of Theta Class Glutathione Transferase : Studies of Recombinant Libraries and Enhancement of Activity toward the Anticancer Drug 1,3-bis(2-Chloroethyl)-1-nitrosourea

    Författare :Anna-Karin Larsson; Bengt Mannervik; Ian Cotgreave; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; glutathione transferase; directed evolution; 1; 3-bis 2-chloroethyl -1-nitrosourea; alkyltransferase; recombinant libraries; chloroethylnitrosourea; multi-dimensional data analysis; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Glutathione transferases (GSTs) are detoxication enzymes involved in the cellular protection against a wide range of reactive substances. The role of GSTs is to catalyze the conjugation of glutathione with electrophilic compounds, which generally results in less toxic products. LÄS MER

  3. 27. Non-target Effects of Genetically Modified Trees

    Författare :Patrik Blomberg; Anders Wennström; Jan Stenlid; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetically modified; GM trees; secondary metabolism; phytochemistry; Populus; transgenic; non-target effects; natural enemies; plant-pathogen herbivore interaction; environmental effects; parasitic fungi; herbivorous insect; Terrestrial ecology; Terrestisk ekologi;

    Sammanfattning : To date, few studies have focused on the effects of genetically modified trees (GM trees) on the environment. One concern with GM trees is that they may have unanticipated effects on non-target organisms, i.e. effects on organisms that are not direct targets of the genetically modified trait. LÄS MER

  4. 28. Studies on lipid transport and extracellular vesicle production in Caenorhabditis elegans ciliated neurons

    Författare :Shapour Rahmani; Simon Tuck; Jonathan D. Gilthorpe; Anders Olsen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C. elegans; cilia; extracellular vesicles; tat; phospholipid translocase; P4-family ATPase;

    Sammanfattning : The cilium is a protrusion of cell membrane. Both the protein and lipid contents of cilia are different from those of other parts of the cell membrane. While the transport of proteins into and out of cilia has been intensively studied, much less is known about how the lipid content of ciliary membranes is regulated. LÄS MER

  5. 29. Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246

    Författare :Jinfeng Shen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in cell cycle arrest, senescence, apoptosis, etc. Mutations in p53 occur frequently (around 50%) in many human tumors. LÄS MER

  7. 30. The kynurenine pathway and development of schizophrenia : immunological and genetic aspects

    Författare :Maria Holtze; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Schizophrenia is a complex disorder with symptoms ranging from hallucinations to poor social functioning and cognitive deficits. Despite decades of research, the etiology of the disease remains puzzling. Genetic aberrations as well as exposure to infection during early life are associated with an increased risk for development of the disease. LÄS MER