Sökning: "wild-type"
Visar resultat 6 - 10 av 1021 avhandlingar innehållade ordet wild-type.
6. Immunoregulation of experimental autoimmune neurirtis focuses on cell immunity
Sammanfattning : Experimental autoimmune neuritis (EAN) is a CD4+ T cell mediated autoimmune disease of peripheral nervous system (PNS). EAN can be induced in susceptible animal strains by active immunization with peripheral nerve tissue, the purified peripheral nerve myelin components P2 and PO, or synthetic P2 and PO peptides. LÄS MER
7. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise
Sammanfattning : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. LÄS MER
8. Mutational analysis of melanocortin receptors 1 and 5
Sammanfattning : The melanocortin receptor family includes five subtypes, named MC1R to MC5R. Melanocortin receptors are predominantly coupled to second messenger pathway of cyclic AMP through coupling to G-protein. This study is focused on structure-function relationship of MC1R and MC5R. LÄS MER
9. Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
Sammanfattning : Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. LÄS MER
10. Design of Glutathione Transferase Variants for Novel Activities with Alternative Substrates
Sammanfattning : Glutathione transferases (GSTs) play a pivotal role in cellular defense, since they are main contributors to the inactivation of genotoxic compounds of exogenous and endogenous origins. Directed evolution was used to improve the catalytic activities of Theta class GST T1-1 toward different substrates. LÄS MER