Sökning: "voltage-gated Na channels"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden voltage-gated Na channels.

  1. 1. Molecular mechanisms of local anaesthetic action on voltage-gated ion channels

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neuroscience

    Författare :Johanna Nilsson; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In this thesis I try to clarify some molecular mechanisms of local anaesthetic action on ion channels. The traditional view is that local anaesthetics eliminate action potentials by a direct block of Na channels. Other mechanisms, however, have been suggested. LÄS MER

  2. 2. Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function

    Detta är en avhandling från Islet cell exocytosis, Dept of Clinical Scinces

    Författare :Vishal Ashok Salunkhe; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; exocytosis; Ca2 ; miR-375; miR-335; rosuvastatin; voltage-gated Na channels; STXBP1; SNAP25; SYT11; glucose homeostasis; beta cell function;

    Sammanfattning : Popular Abstract in Swedish När vi äter ökar nivån av blodsocker (blodglukos) i blodet. Glukos forslas i blodet till målvävnader, såsom fett och skelettmuskel, där det används som energi. Men för att glukos ska kunna tas upp av målvävnaden krävs insulin. LÄS MER

  3. 3. Dendritic and axonal ion channels supporting neuronal integration From pyramidal neurons to peripheral nociceptors

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Marcus Petersson; KTH.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; computational modeling; simulations; dendrites; axons; TRP; hippocampus; C-fiber nociceptors; pain;

    Sammanfattning : The nervous system, including the brain, is a complex network with billions of complex neurons. Ion channels mediate the electrical signals that neurons use to integrate input and produce appropriate output, and could thus be thought of as key instruments in the neuronal orchestra. LÄS MER

  4. 4. K+ channels and the regulation of synaptic transmission

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neuroscience

    Författare :Evanthia Nanou; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to characterize the Na+-activated K+ (KNa) and the Ca2+-activated K+ (KCa) channels and to determine their role in regulating synaptic transmission in the lamprey spinal cord. LÄS MER

  5. 5. Mechanisms of type 1 diabetic serum-induced hyperactivation of CaV1 channels in the pancreatic β cell

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :Yue Shi; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The pancreatic β cell relies on appropriate Ca2+ entry through voltage-gated calcium (CaV) channels to accomplish its unique function insulin secretion and to guarantee its viability. Well-regulated β cell CaV channels are critical to ensure adequate functional β cell mass, thereby maintaining adequate insulin release and glucose homeostasis in the body. LÄS MER