Sökning: "voltage-gated Na channels"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden voltage-gated Na channels.

  1. 1. Molecular mechanisms of local anaesthetic action on voltage-gated ion channels

    Författare :Johanna Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis I try to clarify some molecular mechanisms of local anaesthetic action on ion channels. The traditional view is that local anaesthetics eliminate action potentials by a direct block of Na channels. Other mechanisms, however, have been suggested. LÄS MER

  3. 2. Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function

    Författare :Vishal Ashok Salunkhe; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; exocytosis; Ca2 ; miR-375; miR-335; rosuvastatin; voltage-gated Na channels; STXBP1; SNAP25; SYT11; glucose homeostasis; beta cell function;

    Sammanfattning : Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. LÄS MER

  4. 3. Dendritic and axonal ion channels supporting neuronal integration : From pyramidal neurons to peripheral nociceptors

    Författare :Marcus Petersson; Erik Fransén; Theodore Cummins; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; computational modeling; simulations; dendrites; axons; TRP; hippocampus; C-fiber nociceptors; pain;

    Sammanfattning : The nervous system, including the brain, is a complex network with billions of complex neurons. Ion channels mediate the electrical signals that neurons use to integrate input and produce appropriate output, and could thus be thought of as key instruments in the neuronal orchestra. LÄS MER

  5. 4. K+ channels and the regulation of synaptic transmission

    Författare :Evanthia Nanou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to characterize the Na+-activated K+ (KNa) and the Ca2+-activated K+ (KCa) channels and to determine their role in regulating synaptic transmission in the lamprey spinal cord. LÄS MER

  7. 5. Mechanisms of type 1 diabetic serum-induced hyperactivation of CaV1 channels in the pancreatic β cell

    Författare :Yue Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pancreatic β cell relies on appropriate Ca2+ entry through voltage-gated calcium (CaV) channels to accomplish its unique function insulin secretion and to guarantee its viability. Well-regulated β cell CaV channels are critical to ensure adequate functional β cell mass, thereby maintaining adequate insulin release and glucose homeostasis in the body. LÄS MER