Sökning: "voltage-gated Na channels"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden voltage-gated Na channels.

  1. 6. Transducer properties of a mechanoreceptor : an electrophysiological and pharmacological study of the crayfish stretch receptor

    Författare :Jiahui Lin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :stretch receptor; Na channels; K channels; local anesthetics; calmodulin antagonist; patch clamp; voltage clamp;

    Sammanfattning : The abdominal stretch receptor organ of the crayfish, an analog to the human muscle spindle, contains one slowly adapting (SA) and one rapidly adapting (RA) receptor neuron. The general aims of this project were to elucidate, in the SA and RA neurons, the participation of voltagegated Na+ and K+ channels in overall transducer process and adaptation, and to study possible blocking agents specific to mechanosensitive (MS) channels. LÄS MER

  3. 7. Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations

    Författare :Per Uhlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Calcium; Ca2 signalling; Ca2 oscillation; InsP3; InsP3 receptor; Na; K-ATPase; ouabain; physical interaction; FRET; spectral analysis; confocal microscopy;

    Sammanfattning : Signal transduction via ion fluxes is of vital importance for all mammalian cells. Cells can exploit ion regulatory mechanisms to generate and transmit intracellular signals. Improvements in digital microscopic imaging technology have made it possible to explore micro-environments and complex intracellular machineries. LÄS MER

  4. 8. Regulation of glucagon secretion from pancreatic alpha cells

    Författare :Yang De Marinis; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epac2; glucagon secretion; pancreatic alpha cells; K- ATP channel; N-type Ca2 channel; L-type Ca2 channel; GLP-1; cAMP; PKA; Adrenaline; PKC;

    Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER

  5. 9. Quantitative bioimaging in single cell signaling

    Författare :Kristoffer Bernhem; Hjalmar Brismar; Anita Aperia; Lena Scott; Christian Eggeling; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Super resolution imaging; fluoresence; bioimaging; cells; FRET; cluster analysis; labeling; image analysis.;

    Sammanfattning : Imaging of cellular samples has for several hundred years been a way for scientists to investigate biological systems. With the discovery of immunofluorescence labeling in the 1940’s and later genetic fluorescent protein labeling in the 1980’s the most important part in imaging, contrast and specificity, was drastically improved. LÄS MER

  7. 10. Ion homeostasis in control of stem cell proliferation

    Författare :Shaimaa Abdelhady; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ion homeostasis is critically maintained in all cells by a combined effort from various ion channels, transporters, pumps, and gap junctions. Ion fluxes are essential in excitable cells as they regulate the excitability of the cells and initiate and propagate action potentials. LÄS MER