Sökning: "virulence factor genes"

Visar resultat 6 - 10 av 53 avhandlingar innehållade orden virulence factor genes.

  1. 6. A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach

    Författare :Sara Garbom; Hans Wolf-Watz; Dan Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Yersinia; T3SS; virulence associated genes; VagH; HemK PrmC; Release factors; small molecular inhibitors; HTS; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Bacterial infections are again becoming difficult to treat because the microbes are growing increasingly resistant to the antibiotics in use today. The need for novel antimicrobial compounds is urgent and to achieve this new targets are crucial. In this thesis we present a strategy for identification of such targets via a bioinformatics approach. LÄS MER

  3. 7. The accessory gene regulator, agr, a system for coordinate control of virulence genes in Staphylococcus aureus

    Författare :Eva Morfeldt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bacterial pathogenicity is generally multifactorial, and genes encoding virulence factors are often subject to coordinate regulation. The regulating systems are supposed to adapt the production of virulence factors in response to changes in the environment during the process of infection. LÄS MER

  4. 8. Genetic approaches towards understanding penumococcal virulence and biology

    Författare :Jenny Fernebro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae, the pneumococcus, is a major human pathogen giving rise to death and illness worldwide every year. It causes a wide variety of diseases, from normally harmless infections such as otitis media to potentially life-threatening systemic diseases such as pneumonia, meningitis and sepsis. LÄS MER

  5. 9. Modulators of Vibrio cholerae predator interaction and virulence

    Författare :Barbro Lindmark; Sun Nyunt Wai; Kristian Riesbeck; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; Caenorhabditis elegans; PrtV; outer membrane vesicles; non-O1 non-O139; serum resistance; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Vibrio cholerae, the causal agent of cholera typically encodes two critical virulence factors: cholera toxin (CT), which is primarily responsible for the diarrhoeal purge, and toxin-co-regulated pilus (TCP), an essential colonisation factor. Nontoxigenic strains expressing TCP can efficiently acquire the CT gene through lysogenic conversion with CTXΦ, a filamentous phage that encodes CT and uses TCP as a receptor. LÄS MER

  7. 10. Pathogenecity-associated genes modulate Escherichia coli adhesion and motility

    Författare :Annika E. Sjöström; Bernt Eric Uhlin; Ann-Beth Jonsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Escherichia coli strains typical of UPEC (uropathogenic E. coli) and NBM (newborn meningitis) isolates carry chromosomally located PAIs (pathogenicity islands) that are absent in non-pathogenic E. coli strains. The PAIs include genes for virulence factors such as toxins and genes coding for specific adhesins and pili/fimbriae formation. LÄS MER