Sökning: "translation initiation region"

Visar resultat 11 - 15 av 27 avhandlingar innehållade orden translation initiation region.

  1. 11. Exploring mTOR-dependent regulation of mRNA translation in cancer

    Författare :Hui Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation step during mRNA translation. Subsets of transcripts are discriminated by structural and/or sequence features, and encode proteins involved in different biological functions. LÄS MER

  3. 12. Study of the Link between Translation Termination and Ribosome Biogenesis

    Författare :Magdalena Kaczanowska; Monica Rydén Aulin; Catherine L. Squires; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Mikrobiologi;

    Sammanfattning : Release factor 1 (RF1) is a ribosome-binding protein required for termination of translation in Escherichia coli. To study the effect of slow termination on protein synthesis, two isolated suppressors to a temperature sensitive (Ts) mutant allele of RF1 were studied. LÄS MER

  4. 13. Untangling the contribution of untranslated regions to mRNA translation in health and disease

    Författare :Johannes Ristau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein homeostasis is essential for living organisms and a consequence of steps of the gene expression pathway such as transcription, mRNA translation as well as the degradation of mRNA and proteins. These major cellular events demand tight control, high maintenance, and require a large proportion of cellular resources. LÄS MER

  5. 14. A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation

    Författare :Dmitri Nashchekin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immediately upon transcription, messenger RNA molecules become associated with proteins to form ribonucleoprotein (RNP) complexes, usually called mRNP particles. The mRNPs are the actual targets for regulation and dictate the fate of an mRNA in the gene expression pathway. LÄS MER

  7. 15. Small RNA-mediated Regulation of Gene Expression in Escherichia coli

    Författare :Cecilia Unoson; E. Gerhart. H Wagner; Renée Schroeder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small RNA; non-coding RNA; antisense; translational control; ribosome standby; toxin-antitoxin; IstR; TisB; tisAB; MicF; Lrp; Microbiology; Mikrobiologi; Cell and molecular biology; Cell- och molekylärbiologi; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Non-coding RNAs are highly abundant regulators of gene expression in all kingdoms of life that often play important roles in vital cellular functions. In bacteria, small regulatory RNAs (sRNAs) usually act post-transcriptionally by regulating mRNAs through base pairing within ribosome binding sites (RBS), thereby inhibiting translation initiation. LÄS MER