Sökning: "IstR"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet IstR.

  1. 1. Small RNA-mediated Regulation of Gene Expression in Escherichia coli

    Författare :Cecilia Unoson; E. Gerhart. H Wagner; Renée Schroeder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small RNA; non-coding RNA; antisense; translational control; ribosome standby; toxin-antitoxin; IstR; TisB; tisAB; MicF; Lrp; Microbiology; Mikrobiologi; Cell and molecular biology; Cell- och molekylärbiologi; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Non-coding RNAs are highly abundant regulators of gene expression in all kingdoms of life that often play important roles in vital cellular functions. In bacteria, small regulatory RNAs (sRNAs) usually act post-transcriptionally by regulating mRNAs through base pairing within ribosome binding sites (RBS), thereby inhibiting translation initiation. LÄS MER

  3. 2. Small RNAs, Big Consequences : Post-transcriptional Regulation and Adaptive Immunity in Bacteria

    Författare :Mirthe Hoekzema; Gerhart E. H. Wagner; Magnus Lundgren; Kai Papenfort; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; small RNA; sRNA; non-coding RNA; Hfq; gene regulation; post-transcriptional regulation; biofilm; OmrA; OmrB; toxin-antitoxin; TisB; IstR-1; Persisters; CRISPR-Cas; CRISPR-Cas adaptation reporter; Escherichia coli; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : It is nowadays widely accepted that non-coding RNAs play important roles in post-transcriptional regulation of genes in all kingdoms of life. In bacteria, the largest group of RNA regulators are the small RNAs (sRNAs). LÄS MER

  4. 3. Vessel occlusion and functional outcome after acute stroke : prediction and evaluation

    Författare :Charith Cooray; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the acute setting of ischaemic stroke, two proven treatments are available: intravenous thrombolysis (iv-tPA) with alteplase and endovascular thrombectomy. The main aim of this thesis was to investigate the associations between symptom severity in the acute setting of ischaemic stroke and 1) the presence of arterial occlusions and 2) long-term functional outcome assessed at 3 months. LÄS MER

  5. 4. Treatment and logistics of acute ischemic stroke : safety and outcomes

    Författare :Boris Keselman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Stroke, both ischemic and hemorrhagic, accounts for over 20000 hospital admissions in Sweden yearly. The vast majority of patients (85%), suffer from ischemic stroke, an occlusion of a cerebral artery that can be treated pharmacologically with systemic intravenous thrombolysis (IVT) or mechanically with endovascular thrombectomy (EVT). LÄS MER

  7. 5. Large cerebral artery occlusion and recanalisation in stroke patients treated with intravenous thrombolysis : clinical and radiological markers and their clinical relevance

    Författare :Tatiana Kharitonova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Large cerebral artery occlusion accounts for 40-46% of ischemic strokes. These strokes are characterized by extensive neurological deficit, poor functional outcome, and increased mortality (up to 40-80% in the most severe clinical syndromes). LÄS MER