Sökning: "transforming growth factor-β TGF-β"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden transforming growth factor-β TGF-β.

1. 11. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression

   Författare :Karthik Aripaka; Maréne Landström; Jonas von Hofsten; Carl-Henrik Heldin; Ruth Palmer; Lars-Gunnar Larsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRAF6; HIF-1α; HIF-2α; HIF-3α; ALK5; Wnt3a; Hypoxic signalling; TGF-β; zebrafish; β-Catenin; Pathology; patologi; Oncology; onkologi;

   Sammanfattning : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. LÄS MER

3. 12. Growth factor receptor signalling in thyrocytes of normal and neoplastic origin

   Författare :Daniel Bergström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; thyroid; carcinoma; HGF; Met; TGF-β; EGF; receptor signalling; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : Cellular growth and function are controlled by stimulatory and inhibitory factors actingthrough specific receptors. The present thesis focuses on the role of growth factors, theirreceptors and signalling pathways in normal and neoplastic thyroid epithelial cell biology. LÄS MER

4. 13. Posterior capsule opacification : An experimental study in vitro and in vivo

   Författare :Niklas Wallentin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Posterior capsule opacification PCO ; after-cataract; lens epithelial cell; proliferation; aqueous humor AqH ; inflammation; growth factors; basic fibroblast growth factor bFGF ; transforming growth factor-β TGF-β ; extracapsular cataract extraction; corneal incision; rabbit; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

   Sammanfattning : The clinical and economic significance of posterior capsule opacification (PCO) makes it an important public health problem. A better understanding of the pathogenesis in order to reduce/prevent PCO is needed. For this purpose an experimental model in the rabbit was used and further developed in thisthesis. LÄS MER

5. 14. Regulation of TGF-β/Smad Signaling Through Smad Interacting Proteins

   Författare :Fumiko Itoh; Carl-Henrik Heldin; Peter ten Dijke; Carlos F. Ibáñez; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Transforming growth factor-β (TGF-β) superfamily members are multi-functional regulators of cell fate. These factors signal by binding to a limited number of highly conserved transmembrane type I and type II serine/threonine kinase receptors. These receptors initiate signals into the cell via the Smad proteins. LÄS MER

7. 15. Epigenetic Regulation of Replication Timing and Signal Transduction

   Författare :Rosita Bergström; Aristidis Moustakas; Carl-Henrik Heldin; Rolf Ohlsson; Alain Mauviel; Uppsala universitet; []
   Nyckelord :Cell and molecular biology; Chromatin; CTCF; Epigenetics; Genomic Imprinting; H19; Id; Igf2; Insulator; Replication; Signal Transduction; Smad; TGF-β; Transcription; Cell- och molekylärbiologi;

   Sammanfattning : Upon fertilization the paternal and maternal genomes unite, giving rise to the embryo, with its unique genetic code. All cells in the human body are derived from the fertilized ovum: hence they all contain (with a few exceptions) the same genetic composition. LÄS MER