Sökning: "transcriptional switch"

Visar resultat 21 - 25 av 59 avhandlingar innehållade orden transcriptional switch.

1. 21. Microenvironmental control and molecular detection of neural stem cell state and fate

   Författare :Shirin Ilkhanizadeh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neural stem cell growth and specialization is dependent on microenvironmental cues, such as growth factors, oxygen levels and substrate stiffness. Together these cues define the genetic and epigenetic program of neural stem cells. In our studies we have manipulated these cues in order to achieve better control of neural stem cell state and fate. LÄS MER

3. 22. Studies on Molecular Genetics of B cell Development

   Författare :Panagiotis Tsapogas; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin; gene expression; B cell; EBF; class switching; TGF-beta; Immunology; transplantation; serologi; Immunologi; serology;

   Sammanfattning : The development of immature progenitor cells into highly differentiated effector cells is a process central in modern medicine with applications in the fields of cell therapy as well as oncology. This thesis is focused on the molecular mechanisms that control the development of B lymphocytes. LÄS MER

4. 23. The odyssey of MYC transcript from the nucleus to the cytoplasm : the molecular mechanism of the gene gating in human cancer cells

   Författare :Mirco Martino; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pathological expression of the MYC oncogene is a common denominator in a wide range of cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene benefits from being embedded in a region rich in enhancers and super-enhancers that are often absent in the normal cell counterparts. LÄS MER

5. 24. Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression

   Författare :Monika Somberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

   Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. We speculate that inhibition of HPV-16 late gene expression is a prerequisite for establishment of persistence and progression to cervical cancer. LÄS MER

7. 25. Switching ON Fetal B Lymphopoiesis

   Författare :Trine Kristiansen; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B-1 B cells; Lin28; Fetal hematopoietic stem cells;

   Sammanfattning : B-1a cells are innate-like lymphocytes that develop primarily during fetal and neonatal life, whereas adult bone marrow (BM) hematopoietic stem cells (HSCs) preferentially give rise to follicular B-2 cells. Functioning at the interface of the innate and adaptive immune systems, B-1a cells provide a non-redundant first line of defense prior to the temporally delayed establishment of a B-2 cell response. LÄS MER