Sökning: "toxicity testing"

Visar resultat 36 - 40 av 68 avhandlingar innehållade orden toxicity testing.

  1. 36. New vanadium oxido complexes with potential biological activity

    Författare :Jessica Nilsson; Kemisk fysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Several biological aspects of vanadium are known and even though it has not been proven to be an essential metal for humans, it might have implication as a drug against the disease diabetes mellitus. However, undesired side effect as a result of the toxicity of vanadium must be reduced. LÄS MER

  3. 37. Chemosensitivity in Breast Cancer

    Författare :Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
    Nyckelord :Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

    Sammanfattning : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. LÄS MER

  4. 38. In vitro studies of cytostatic drugs and growth factors on leukemic and normal hematopoietic cells : based on in vivo intracellular pharmacokinetics

    Författare :Britt Sundman-Engberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ANLL; Normal bone marrow; in vitro; predictive tests; pharmacokinetics; cytostatic drugs; growthfactors;

    Sammanfattning : The aims were to develop, evaluate and apply in vitro methods for cytostatic drug sensitivity, based on intracellular concentrations found after in vivo infusions. The intracellular pharmacokinetics of anthraquinones and ara-C were compared during and after infusion to leukemic patients. Drug concentrations were evaluated with HPLC. LÄS MER

  5. 39. Bioanalytical studies of designer benzodiazepines

    Författare :Madeleine Pettersson Bergstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The fast appearance of benzodiazepine analogues, referred to as new psychoactive substance (NPS) or designer benzodiazepines, requires the continuous update of detection methods in order to keep up with the latest drugs on the recreational drug market. Moreover, as usually only limited information on toxicity and excretion patterns of these new drugs exists, this needs to be evaluated to report on adverse effects and to determine suitable targets for drug testing. LÄS MER

  7. 40. Particulate airborne impurities : express analysis and health effects

    Författare :Kai Wilkinson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The cumulative effects of air pollutants are of principal concern in research on environmental protection in Sweden. Post-industrial society has imposed many limits on emitted air pollutants, yet the number of reports on the negative effects from them is increasing, largely due to human activity in the form of industrial emissions and increased traffic flows. LÄS MER