Sökning: "anthracycline"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet anthracycline.

  1. 1. Anthracyclines : Toxicity and chemotherapy-induced mucositis

    Författare :Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. LÄS MER

  3. 2. Chemosensitivity in Breast Cancer

    Författare :Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
    Nyckelord :Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

    Sammanfattning : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. LÄS MER

  4. 3. Anthracycline pharmacodynamics and pharmacokinetics in acute myeloid leukemia

    Författare :Alex Bogason; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The goal of this thesis has been to study pharmacodynamics and pharmacokinetics of anthracyclines in acute myeloid leukemia (AML) with the ultimate goal to improve chemotherapy: 1. By studying the relation between daunorubicin (DNR) and idarubicin (IDA) uptake in vitro and in vivo and apoptosis in vitro in leukemic cells isolated from patients with AML. LÄS MER

  5. 4. Two-Step Targeting for Effective Radionuclide Therapy : Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

    Författare :Amelie Fondell; Lars Gedda; Detlef Gabel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. LÄS MER

  7. 5. Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines

    Författare :Kerstin Jönsson Videsäter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multidrug resistance; cross-resistance profile; ATP-bioluminescence assay; pglycoprotein; MRP1; selenium; thioredoxin reductase; glutathione reductase.;

    Sammanfattning : Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of multidrug resistance and to establish in vitro methods to characterize the resistant tumor cell phenotype. LÄS MER