Sökning: "tissue culture verapamil portal vein patch-clamp calcium spermidine spermine polyamines excitation-contraction smooth muscle calcium channel ionomycin. Physiology Fysiologi"
Hittade 2 avhandlingar innehållade orden tissue culture verapamil portal vein patch-clamp calcium spermidine spermine polyamines excitation-contraction smooth muscle calcium channel ionomycin. Physiology Fysiologi.
1. Calcium channel activity and force regulation in smooth muscle: Effects of polyamines and growth stimulation
Sammanfattning : The initial signal for contraction in smooth muscle is an increase in [Ca2+]i. Ca2+ ions can either enter the cytosol from the extracellular medium or be released from intracellular stores. Voltage-operated Ca2+ channels (VOC) play a dominant role in the activation of smooth muscle contraction. LÄS MER
2. Modulation of the calcium-force relationship in smooth muscle by polyamines and metabolic inhibition
Sammanfattning : The relationship between intracellular free calcium ([Ca2+]i) and force in smooth muscle was investigated in receptor-coupled permeabilized preparations and by fluorimetry of the calcium indicator Fura 2 in intact smooth muscle. The time integral of spontaneous [Ca2+]i transients in the intact rat portal vein was decreased by cyanide and, during tonic contraction, cyanide reduced force without changing [Ca2+]i implying metabolic sensitivity of both membrane excitation and [Ca2+]i - activation of the contractile proteins. LÄS MER