Sökning: "thyroid function"

Visar resultat 21 - 25 av 83 avhandlingar innehållade orden thyroid function.

  1. 21. Expression and function of thyroid hormone receptor alpha 1 in the brain

    Författare :Karin Wallis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thyroid hormone is fundamentally important for development and maintenance of adult brain functions and maternal hypothyroxinemia during pregnancy can lead to a severe mental retardation known as endemic cretinism. The first realization that endemic cretinism is caused by iodine deficiency and its association with thyroid hormone was made a century ago; this eventually resulted in dietary supplementation programme, e. LÄS MER

  3. 22. Studies on catecholamine function in human fat cells

    Författare :Lena Hellström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adipose tissue; human; catecholamines; lipolysis; adrenoceptors; mRNAhormone-sensitive lipase; hypo-caloric diet; thyroid hormones.;

    Sammanfattning : Human adipose tissue is a heterogeneous organ as regards metabolism. The effects of catecholamines, the main lipolytic hormones in man vary considerably in different regions. Fat cell lipolysis also changes in a number of physiological and pathophysiological states. LÄS MER

  4. 23. Thyroid function and breast cancer. Risk and clinical outcome in relation to thyroid hormones (free T3/T4), TSH, TPO-Antibodies and genetic variants

    Författare :Jasmine Brandt; Kirurgi; []
    Nyckelord :Sköldkörtel; Thyroidea; Bröstcancer;

    Sammanfattning : Thyroid hormone level has been positively associatedwith breast cancer cell proliferation andtumour growth in experimental studies. However,previous observational studies have been contradictoryon the relationship between thyroidfunction and breast cancer. Age is a known riskfactor for breast cancer but its role as a prognosticfactor is less clear. LÄS MER

  5. 24. Regulation of gene transcription by the thyroid hormone receptors

    Författare :Maria Nygård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid hormone receptors; T3; cell differentiation; gene regulation; E2F-1; Necdin; TRH; nTRE; RXR; NCoR; XAP-2;

    Sammanfattning : Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha and TRbeta genes, respectively. TRs belong to the nuclear hormone receptor superfamily. LÄS MER

  7. 25. Genetic and functional studies on the thyroid hormone axis

    Författare :Abdelaziz Elgadi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. LÄS MER