Sökning: "thyroid function"

Visar resultat 11 - 15 av 83 avhandlingar innehållade orden thyroid function.

1. 11. Taking Pressure of Anaplastic Thyroid Carcinoma : Molecular Studies of Apoptosis and Interstitial Hypertension

   Författare :Pernilla Roswall; Nils-Erik Heldin; Kristofer Rubin; Sven Påhlman; Uppsala universitet; []
   Nyckelord :Medicine; Anaplastic thyroid carcinoma; Apoptosis; Cre recombinase; 2-Methoxyestradiol; Transforming growth factor-β; Transgenic mouse; Tumor-associated macrophages; Tumor interstitial fluid pressure; Medicin;

   Sammanfattning : Molecular mechanisms in the development and progression of thyroid carcinomas are still not fully understood. In the present thesis the highly malignant anaplastic thyroid carcinoma (ATC) was used to study regulation of apoptosis and tumor interstitial fluid pressure (IFP). LÄS MER

3. 12. Preservation of parathyroid function in thyroid and parathyroid surgery

   Författare :Stefan Ander; Göran Åkerström; Linköpings universitet; []
   Nyckelord :Human parathyroid glands; vascular supply; parathyroid preservation; laser Doppler flowmetry; iPTH; autotransplantation; xenotransplantation; a thymic mice; angiogenesis; immunohistochemistry; electron microscopy; ultrastructure; autoradiography; MEDICINE; MEDICIN;

   Sammanfattning : Preservation of normal parathyroid function and calcium homeostasis after operations on the thyroid and parathyroid glands is a difficult assignment in endocrine surgery, and it is crucial to minimise the risks of permanent postoperative hypoparathyroidism. The aim of this thesis was to study the vascular supply of the parathyroid glands and the revascularisation, growth, and function of transplanted parathyroid tissue, in order to add new information about parathyroid preservation. LÄS MER

4. 13. Recurrent unexplained first-trimester miscarriage. Effects of acetylcalicylic acid, platelet aggregation and thyroid disease

   Författare :Lennart Blomqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acetylsalicylic acid; recurrent miscarriage; platelet aggregation; pregnancy; early pregnancy; first-trimester; live birth; impedance aggregometry; thyroid stimulating hormone; levothyroxine; thyroid peroxidase antibody; arachidonic acid-induced platelet aggregation; platelet activators;

   Sammanfattning : Recurrent unexplained first-trimester miscarriage. Effects of acetylsalicylic acid, platelet aggregation and thyroid disease. Lennart Blomqvist, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden, 2019. LÄS MER

5. 14. In vitro studies on the mechanisms of inhibited thyroidal iodide uptake and destructive thyroiditis as adverse effects of amiodarone and interferon-gamma

   Författare :Sofia Tedelind; Göteborgs universitet; []
   Nyckelord :thyroid; amiodarone; interferon-gamma; iodide transport; tight junction; mitochondria; endocytosis;

   Sammanfattning : The clinical use of the potent anti-arrhythmic drug amiodarone is limited due to adverse effects e.g. in the thyroid comprising both hypo- and hyperthyroidism. Amiodarone-induced thyroid dysfunction can occur in subjects with normal thyroid glands but also in those with an underlying thyroid abnormality resulting in an aggravation of the condition. LÄS MER

7. 15. Aspects of chronic autoimmune thyroiditis in children and adolescents

   Författare :Johan Svensson; Pediatrisk endokrinologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescents; thyroid autoantibodies; enterovirus infection; thyroid ultrasonography; reference standard; goiter; chronic autoimmune thyroiditis; levothyroxine treatment; Medicin människa och djur ; Medicine human and vertebrates ; children;

   Sammanfattning : The aims of this thesis were to 1) compare different methods for detection of antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb), particulary in children with chronic autoimmune thyroditis (AIT), 2) investigate if maternal enterovirus infection is a risk factor for development of AIT in offspring, 3) ascertain the prevalence of thyroid autoantibodies in cord blood sera from children who later developed AIT, 4) develop a new reference standard for interpretation of normative thyroid volumes in Swedish children, and 5) evaluate the effect of Levothyroxine (L-thyroxine) treatment on thyroid size in children and adolescents with AIT. We found that 1) Methods based on radioimmunoassay (RIA) were more efficient in detecting both TgAb and TPOAb in children with AIT than methods based on agglutination. LÄS MER