Sökning: "synteny"

Visar resultat 11 - 15 av 21 avhandlingar innehållade ordet synteny.

  1. 11. Evolution of Vertebrate Vision by Means of Whole Genome Duplications : Zebrafish as a Model for Gene Specialisation

    Författare :David Lagman; Dan Larhammar; Xesús M Abalo; Finn Hallböök; Stephan Neuhauss; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; evolution; vision; visual opsin; transducin; PDE6; genome duplications; subfunctionalisation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The signalling cascade of rods and cones use different but related protein components. Rods and cones, emerged in the common ancestor of vertebrates around 500 million years ago around when two whole genome duplications took place, named 1R and 2R. LÄS MER

  3. 12. Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1

    Författare :Åke Västermark; Helgi Schiöth; Arne Elofsson; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Integral membrane proteins play a key role hormonal and neuronal signaling. Transmembrane helix (TM) proteins form about 27% of the human proteome. Furthermore, 44% of the human drug targets are receptors, and 19% of these are seven-transmembrane domain receptors (GPCRs), which constitute 4% of the entire protein-coding genome. LÄS MER

  4. 13. Molecular evolution of the neuropeptide Y receptor family : Insights from mammals and fish

    Författare :Amanda Wraith; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Most genes in the genomes of vertebrates form families with multiple members that are more or less closely related. This thesis concerns investigations of the neuropeptide Y (NPY) family of peptides and the family of receptors to which these peptides bind, the NPY receptors. LÄS MER

  5. 14. Taking advantage of phylogenetic trees in comparative genomics

    Författare :Örjan Åkerborg; Jens Lagergren; Mathieu Blanchette; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer Science; Bioinformatics; Bioinformatik;

    Sammanfattning : Phylogenomics can be regarded as evolution and genomics in co-operation. Various kinds of evolutionary studies, gene family analysis among them, demand access to genome-scale datasets. But it is also clear that many genomics studies, such as assignment of gene function, are much improved by evolutionary analysis. LÄS MER

  7. 15. Genome mapping of the horse

    Författare :Gabriella Lindgren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Horse; microsatellites; linkage analysis; FISH; Type I markers; BAc library; Y chromosome; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Evolutionary Genetics; evolutionär genetik;

    Sammanfattning : Our ability to map and sequence whole genomes is one of the most important developments in biological science. It will provide us with an unprecedented insight into the genetic background of phenotypic traits, such as disease resistance, reproduction and growth and also makes it feasible to study the processes of genome evolution. LÄS MER