Sökning: "synteny"

Visar resultat 6 - 10 av 21 avhandlingar innehållade ordet synteny.

  1. 6. Cloning, Expression, Pharmacological Characterization and Anatomical Distribution of Melanocortin Receptors in an Evolutionary Perspective

    Författare :Aneta I. Ringholm; Helgi B. Schiöth; Dan Larhammar; Björn Olde; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; evolution; melanocortin; MSH; pharmacology; genome duplication; tetraploidization; zebrafish; spiny dogfish; chicken; GPCR; polymorphism; pigmentation; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The melanocortin (MC) receptors are G-protein coupled receptors thatparticipate in several important physiological functions such as the regulation of the energy balance. This thesis focuses on the evolutionary aspect of the MC receptors and their pharmacology.One MC4 receptor and two MC5 receptor subtypes were found in a teleost fish, zebrafish. LÄS MER

  3. 7. From genomes to post-processing of Bayesian inference of phylogeny

    Författare :Raja Hashim Ali; Lars Arvestad; Dannie Durand; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bayesian inference; Computer Science; Datalogi;

    Sammanfattning : Life is extremely complex and amazingly diverse; it has taken billions of years of evolution to attain the level of complexity we observe in nature now and ranges from single-celled prokaryotes to multi-cellular human beings. With availability of molecular sequence data, algorithms inferring homology and gene families have emerged and similarity in gene content between two genes has been the major signal utilized for homology inference. LÄS MER

  4. 8. Computational Problems in Modeling Evolution and Inferring Gene Families

    Författare :Mehmood Alam Khan; Lars Arvestad; Jens Lagergren; Christophe Dessimoz; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Phylogenetics; Lateral Gene Transfer; Gene Families; Clustering; Datalogi; Computer Science;

    Sammanfattning : Over the last few decades, phylogenetics has emerged as a very promising field, facilitating a comparative framework to explain the genetic relationships among all the living organisms on earth. These genetic relationships are typically represented by a bifurcating phylogenetic tree — the tree of life. LÄS MER

  5. 9. Gene Mapping in Ficedula Flycatchers

    Författare :Niclas Backström; Hans Ellegren; Juha Merilä; Uppsala universitet; []
    Nyckelord :collared flycatcher; SNP; linkage disequilibrium; genetic map; pedigree;

    Sammanfattning : In order to get full understanding of how evolution proceeds in natural settings it is necessary to reveal the genetic basis of the phenotypic traits that play a role for individual fitness in different environments. There are a few possible approaches, most of which stem from traditional mapping efforts in domestic animals and other model species. LÄS MER

  7. 10. Methods and Applications in Comparative Bacterial Genomics

    Författare :Hans-Henrik Fuxelius; Siv Andersson; Björn Andersson; Uppsala universitet; []
    Nyckelord :Biology; Biologi;

    Sammanfattning : Comparative studies of bacterial genomes, now counting in the hundreds, generate massive amounts of information. In order to support a systematic and efficient approach to genomic analyses, a database driven system with graphic visualization of genomic properties was developed - GenComp. LÄS MER