Sökning: "synteny"

Visar resultat 16 - 20 av 21 avhandlingar innehållade ordet synteny.

  1. 16. Genetic regulation of neuroinflammation : a translational approach

    Författare :Johan Öckinger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), causing demyelination and axonal damage. As other complex diseases with an inflammatory or autoimmune component, MHC is a strong regulator of the disease and acts in concert with multiple nonMHC genes and environmental factors. LÄS MER

  3. 17. Hypoxia inducible factor 1alpha : molecular mechanisms of regulation

    Författare :William J Wilson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to hypoxia, including induction of vascular endothelial growth factor (VEGF) gene expression. LÄS MER

  4. 18. Genome characterisation and mobility investigation in trypanosomes

    Författare :Carole Branche; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma brucei - Trypanosoma cruzi - karyotype - genome organisation -flageflum mobility - RNAi - functional studies.;

    Sammanfattning : Trypanosomes are uni-flagellated protozoa responsible for some of the most debilitating human infections such as Chagas disease (Trypanosoma cruzi) and sleeping sickness (Trypanosoma brucei). Unravelling their genome organisation and their biology would improve our basic knowledge and could contribute to find new drug target specific to the species. LÄS MER

  5. 19. Gene complexes and regulatory domains in metazoan genomes

    Författare :Pär Engström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite the recent massive increases in genome and transcript sequence data, including wholegenome sequences for humans and many other metazoans, our understanding of the content of these sequences is far from complete. This thesis is about making use of metazoan sequence data to detect functional genetic elements on a genome-wide scale and examine the distribution of those elements on chromosomes. LÄS MER

  7. 20. Involvement of evolutionarily plastic regions in cancer associated CHR3 aberrations

    Författare :Eva Darai-Ramqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A functional test to identify tumor antagonizing regions on chromosome 3 (chr3), called the Elimination Test, was developed in our group. It is based on microcell mediated transfer of human chr3 into mouse or human tumor cells and analysis of the monochromosomal hybrids after their growth in vivo. LÄS MER