Sökning: "PDE6"
Hittade 3 avhandlingar innehållade ordet PDE6.
1. Evolution of Vertebrate Vision by Means of Whole Genome Duplications : Zebrafish as a Model for Gene Specialisation
Sammanfattning : The signalling cascade of rods and cones use different but related protein components. Rods and cones, emerged in the common ancestor of vertebrates around 500 million years ago around when two whole genome duplications took place, named 1R and 2R. LÄS MER
2. Genes and proteins controlled by cGMP-PKG during retinal degeneration
Sammanfattning : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. LÄS MER
3. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4
Sammanfattning : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. LÄS MER