Sökning: "synapsis"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet synapsis.
1. Chromosome synapsis and recombination in yeast meiosis
Sammanfattning : Meiosis is a cell division process that produces haploid gametes from diploid cells. Several important meiotic events take place during prophase of meiosis I, most important being homologous chromosome pairing, meiotic recombination and formation of the synaptonemal complex (SC). LÄS MER
2. Proteins influencing the integrity of meiotic chromosome dynamics
Sammanfattning : Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called synapsis) and recombination between them. LÄS MER
3. Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis
Sammanfattning : How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which is the leading genetic cause of pregnancy loss in humans. Meiosis is a cell division process that produces genetically unique haploid gametes from diploid cells. LÄS MER
4. Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
Sammanfattning : Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ensures chromosome segregation. Breast cancer susceptibility gene 2 (BRCA2) is a potent cancer suppressor and is required for DSB repair by homologous recombination (HR) in mitosis. LÄS MER
5. Molecular architecture of meiotic chromosomes
Sammanfattning : Faithful chromosome segregation at each cell division is essential as the formation of cells with an abnormal number of chromosomes (aneuploid cells) can result in infertility, developmental defects or cancer. Aneuploidy occurs in approximately 20% of all conceptions, causing infertility and embryo death. LÄS MER