Sökning: "Chromosome architecture"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Chromosome architecture.

  1. 1. Molecular architecture of meiotic chromosomes

    Författare :Ivana Novak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Meiosis; Chromosome architecture; Synaptonemal complex; Cohesin complex;

    Sammanfattning : Faithful chromosome segregation at each cell division is essential as the formation of cells with an abnormal number of chromosomes (aneuploid cells) can result in infertility, developmental defects or cancer. Aneuploidy occurs in approximately 20% of all conceptions, causing infertility and embryo death. LÄS MER

  2. 2. The genetic architecture of sexual dimorphism

    Författare :Robert Griffin; Urban Friberg; Alexei Maklakov; Jon Ågren; Russell Bonduriansky; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; evolution; intralocus sexual conflict; sex chromosomes; sexually antagonistic selection; sexual dimorphism;

    Sammanfattning : Phenotypic differences between the sexes evolve largely because selection favours a different complement of traits in either sex. Theory suggests that, despite its frequency, sexual dimorphism should be generally constrained from evolving because the sexes share much of their genome. LÄS MER

  3. 3. Coiled coil Cytoskeleton in Bacterial Cell Architecture : Studies of Growth and Development in Streptomyces

    Författare :Sonchita Bagchi; Nora Ausmees; Joseph McCormick; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Coiled coil proteins; Bacterial cytoskeleton; Differentiation; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Bacterial cytoskeleton is an exciting and relatively new field of research. Recent findings have proven that microbes are well-organized and neatly structured organisms. LÄS MER

  4. 4. Regulation of chromatin transitions in the 3D architecture of the nucleus

    Författare :Honglei Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation capture assay (4C) and Chromatin in situ Proximity (ChrISP) technique to uncover an inter-chromosomal chromatin fiber interactome comprising both transcriptionally active circadian genes and repressed lamina-associated domains (LADs). LÄS MER

  5. 5. Evolutionary dynamics of migration and breeding in wild birds: genetic architecture, sexual conflicts and evolutionary constraints

    Författare :Maja Tarka; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; quantitative genetics; heritability; intralocus sexual conflict; antagonistic selection; QTL; G-matrix; wing length; arrival date; migration; geolocator; bird; Acrocephalus arundinaceus;

    Sammanfattning : Our knowledge of the evolutionary potential of traits involved in different selective episodes, especially in natural populations, is still limited. This is true for questions such as the genetic basis and inheritance of traits, how natural and sexual selection acts on them, and how selective conflicts influence the evolutionary response to selection. LÄS MER