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Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.
1. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy
Sammanfattning : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. LÄS MER
2. The Xenopus tropicalis model for developmental endocrine and reproductive toxicity : Histological and molecular endpoints for disrupted spermatogenesis
Sammanfattning : Endocrine disrupting chemicals (EDCs) are linked to adverse effects in both humans and wildlife. There are however, large knowledge gaps regarding cause-effect and dose-response relationships between the interference with endocrine pathways and adverse effects in the organism, especially at puberty and in subsequent generations. LÄS MER
3. Novel culture systems to model testicular function and organization
Sammanfattning : In vitro systems to model the testicular microenvironment are required to study physiology and pathology of the testis, the gonadotoxic effect of environmental and pharmaceutical chemicals, as well as to explore the mechanisms ruling spermatogonial stem cell (SSC) self-renewal and differentiation. The knowledge produced in in vitro experiments, using animal, but most importantly utilizing human models, will contribute to the discovery of safe medical treatments and might provide translational tools to treat male infertility problems. LÄS MER
4. Isoforms of mammalian glutaredoxin 2
Sammanfattning : Iron-sulfur proteins are characterized by the presence of iron-sulfur clusters containing sulfide linked iron centers in variable oxidation states. Glutaredoxins (Grx) are, among other redoxins, increasingly recognized to be involved at the interface between redox regulation, iron metabolism and iron-cluster biosynthesis. LÄS MER
5. Mammalian sperm flagella and cilia
Sammanfattning : In mammals, both sperm flagella and cilia are axoneme-containing organelles. The sperm flagella are major parts of the spermatozoa that are male gametes produced in the testis from progenitor spermatogonia through a process called spermatogenesis. LÄS MER
