Sökning: "gammaH2AX"

Hittade 3 avhandlingar innehållade ordet gammaH2AX.

  1. 1. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

    Detta är en avhandling från Medical Radiation Physics, Lund University

    Författare :Suaad Meerkhan; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

    Sammanfattning : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. LÄS MER

  2. 2. Polycyclic aromatic hydrocarbons : DNA damage and cell signaling

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Åse Mattsson; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Oxidative stress is a threat to our wellbeing. The formation of reactive oxygen species may result in oxidative lesions in DNA and RNA. When challenging A549 cells with 18O-labeled hydrogen peroxide, we found that RNA was between 14-25 times more sensitive to [18O]-8-oxoGuo formation than [18O]-8-oxodGuo formation in DNA. LÄS MER

  3. 3. Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Marina Protopopova; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p53 triggers a cell cycle arrest in GI or apoptosis, ensuring a suppression of a tumor development by the elimination of cells carrying potentially tumorigenic lesions. LÄS MER