Sökning: "spermatogonia"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet spermatogonia.

  1. 1. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

    Detta är en avhandling från Medical Radiation Physics, Lund University

    Författare :Suaad Meerkhan; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

    Sammanfattning : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. LÄS MER

  2. 2. Novel culture systems to model testicular function and organization

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Författare :João Pedro Alves Lopes; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In vitro systems to model the testicular microenvironment are required to study physiology and pathology of the testis, the gonadotoxic effect of environmental and pharmaceutical chemicals, as well as to explore the mechanisms ruling spermatogonial stem cell (SSC) self-renewal and differentiation. The knowledge produced in in vitro experiments, using animal, but most importantly utilizing human models, will contribute to the discovery of safe medical treatments and might provide translational tools to treat male infertility problems. LÄS MER

  3. 3. Isoforms of mammalian Glutaredoxin 2

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Författare :Christoph Hudemann; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Iron-sulfur proteins are characterized by the presence of iron-sulfur clusters containing sulfide linked iron centers in variable oxidation states. Glutaredoxins (Grx) are, among other redoxins, increasingly recognized to be involved at the interface between redox regulation, iron metabolism and iron-cluster biosynthesis. LÄS MER

  4. 4. Mammalian sperm flagella and cilia

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Jikui Guan; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In mammals, both sperm flagella and cilia are axoneme-containing organelles. The sperm flagella are major parts of the spermatozoa that are male gametes produced in the testis from progenitor spermatogonia through a process called spermatogenesis. LÄS MER

  5. 5. Artificial testis to study early gonadal development and germ cell differentiation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Författare :Ahmed Reda; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Studying the early germ cell development is of great significance, as germ cells transfer the genetic material between generations. However, in humans, this type of studies in vivo is not applicable, for obvious ethical reasons. LÄS MER