Sökning: "retinal pigment epithelium"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden retinal pigment epithelium.

1. 1. Retinal Transplants: Growth Differentiation Integration Organization and Survival

   Författare :Rajesh Kumar Sharma; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; Retinal transplants; retinal development; treatment; connections; proliferation; survival; Ophtalmology; Oftalmologi;

   Sammanfattning : The goal of the study was to get a better understanding of factors controlling the growth, differen-tia-tion, integration, organization and survival of retinal transplants, with the long-term view of eventually developing retinal transplantation into a clinically useful procedure for treating degenerative retinal disorders such as retinitis pigmentosa. Embryonic day 15 rabbit retinas were transplanted into adult rabbit eyes and were allowed to survive for various times. LÄS MER

3. 2. Photoreceptors in experimental retinal cell transplants

   Författare :Bengt Juliusson; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; immunohistochemistry; mice; rabbits; rats; interphotoreceptor matrix; retinal pigment epithelium; photoreceptors; Retina; transplantation; Oftalmologi;

   Sammanfattning : The main objective of this thesis was to investigate the fate of photoreceptor cells when using different strategies for retinal cell transplantation. Comparing transplantation of fragments of embryonic retina with cell suspensions of the same tissue we found that transplantation of fragments of embryonic retina result in mature transplants with a higher degree of cellular organization than transplantation of cell suspensions of embryonic retina. LÄS MER

4. 3. Bothnia dystrophy, a clinical, genetical and electrophysiological study

   Författare :Marie Burstedt; Ola Sandgren; Ola Textorius; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; retinal pigment epithelium; retinitis pigmentosa; neural retina; electroretinogram; cellular retinaldehyde-binding protein; dark adaptometry; retinal degeneration; Oftalmiatrik; Ophtalmology; Oftalmologi; Ophtalmology; oftalmiatrik;

   Sammanfattning : A high frequency of retinitis pigmentosa (RP) is found in Northern Sweden. In an inventory of autosomal recessive RP patients in Västerbotten County, a great number of cases with a unique phenotype was noticed, denoted Bothnia Dystrophy (BD). LÄS MER

5. 4. The interaction between the neuroretina and the retinal pigment epithelium : an electrophysiological study of the effects of possible messenger substances and their analogues

   Författare :Ragnheiður Bragadóttir; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The retinal pigment epithelium (RPE) is of great importance in photoreceptor homeostasis. The photoreceptors are highly specialized cells which cannot survive without the RPE. It has been postulated that messenger substances are involved in the interaction between the RPE and the inner retina. LÄS MER

7. 5. Models of Retinal Development and Disease

   Författare :Minas Hellsand; Finn Hallböök; Emma Andersson; Department of Cell and Molecular Biology Karolinska Institutet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Developmental neurobiology; retinal organoids; retinoblastoma; MYCN; Stargardt disease; Bardet-Biedl syndrome; model systems;

   Sammanfattning : For a model of a human disease to be valid and useful, it is important that key genotypic and phenotypic traits are shared between model system and human. The work in this thesis has been focused on generating new and characterizing spontaneous models of three genetic disorders affecting the retina: retinoblastoma, a childhood cancer with its origin in the fetal retina, Stargardt disease, a juvenile form of macular degeneration, and Bardet-Biedl syndrome, a pleiotropic ciliopathy featuring retinal degeneration. LÄS MER