Sökning: "protein surfaces"

Visar resultat 1 - 5 av 293 avhandlingar innehållade orden protein surfaces.

  1. 1. Protein folding without loops and charges

    Författare :Martin Kurnik; Mikael Oliveberg; Kevin W. Plaxco; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; folding cooperativity; protein aggregation; protein charges; protein engineering; Biochemistry; biokemi;

    Sammanfattning : Going down the folding funnel, proteins may sample a wide variety of conformations, some being outright detrimental to the organism. Yet, the vast majority of polypeptide molecules avoid such pitfalls. Not only do they reach the native minimum of the energy landscape; they do so via blazingly fast, biased, routes. LÄS MER

  3. 2. Navigating the Cellular Crowd : Physicochemical Properties of Protein Surfaces as Evolved Interaction Guides

    Författare :Eloy Vallina Estrada; Mikael Oliveberg; Erik Lindahl; Gideon Schreiber; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein interactions; inteins; physicochemical properties; protein surfaces; evolution; cellular crowding; electrostatics; Biophysics; biofysik;

    Sammanfattning : The cellular interior is characterised by high concentrations of macromolecules. Compared with dilute conditions, the crowd modifies proteins' ability to fold, diffuse and, ultimately, carry out their biological functions. Cellular fitness depends on ensuring an adequate balance between interactivity and diffusivity. LÄS MER

  4. 3. Protein modularity : Structure and interactions by NMR and SPR

    Författare :Amélie Wallenhammar; Maria Sunnerhagen; Björn Wallner; Lotta Tollstoy-Tegler; Helena Berglund; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Protein degradation is a fundamental cornerstone of regulation of protein levels in the human body. For proper function, numerous molecular processes rely on fine-tuned communication through specific interactions between proteins. LÄS MER

  5. 4. Protein-Protein Interactions Affecting Protein-Surface Interactions

    Författare :Peter H. Warkentin; Jeff M. Schakenraad; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The focus of this thesis is the behaviour of proteins towards surfaces in the presence of other protein species. General protein-protein interactions of some plasma proteins are investigated in the first four papers. The proteins, immunoglobulin G, albumin, and fibrinogen, are analysed in solutions of single proteins as well as controlled mixtures. LÄS MER

  7. 5. Cell-protein-material Interactions on Bioceramics and Model Surfaces

    Författare :Åsa Rosengren; Sven Oscarsson; Lucy Di Silvio; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; protein adsorption; blood proteins; biomaterials; ceramics; glass-ceramics; two-dimensional gel electrophoresis; protein orientation; silicon wafers; atomic force microscopy; bone cell adhesion; divalent cation dependency; Kemi; Chemistry; Kemi;

    Sammanfattning : The objective of this thesis was to investigate and characterize the interaction between blood proteins and different surfaces with emphasis on protein adsorption to bioceramics and model surfaces. Special effort was made to monitor the spontaneous and selective adsorption of proteins from human plasma and to examine the orientation, conformation and functional behavior of single proteins after adsorption. LÄS MER