Sökning: "pooled sequencing"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden pooled sequencing.

  1. 1. A functional genomic investigation of an alternative life history strategy : The Alba polymorphism in Colias croceus

    Författare :Alyssa Woronik; Christopher Wheat; Antonia Monteiro; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alternative life history strategy; butterfly wing color; Alba; Colias; color polymorphism; dimorphism; life history traits; physiology; lipidomics; genomics; pooled sequencing; phylogenomics; RNA-Seq; Pool-Seq; populationsgenetik; Population Genetics;

    Sammanfattning : Life history traits affect the timing and pattern of maturation, reproduction, and survival during an organism’s lifecycle and are the major components influencing Darwinian fitness. Co-evolved patterns of these traits are known as life history strategies (LHS) and variation occurs between individuals, populations, and species. LÄS MER

  3. 2. Application of next generation sequencing in genetic and genomic studies

    Författare :Jingwen Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genetic variants that spread along the human genome play vital roles in determining our traits, affecting development and potentially causing disorders. Most common disorders have complex underlying mechanisms involving genetic or environmental factors and the interaction between them. LÄS MER

  4. 3. Genomic characterization of pediatric acute lymphoblastic leukemia by deep sequencing

    Författare :Carl Mårten Lindqvist; Ann-Christine Syvänen; Gabor Marth; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children, with close to 200 cases per year in the Nordic countries. Despite recent advances in modern chemotherapies, 20% of the ALL patients experience a relapse. LÄS MER

  5. 4. Interrogation of Nucleic Acids by Parallel Threading

    Författare :Erik Pettersson; Joakim Lundeberg; Afshin Ahmadian; Ann-Christine Syvänen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; genotyping; multiplex amplification; trinucleotide threading; single nucleotide polymorphism; genotype calling; Expectation-Maximization; protein-epitope signature tag; expression profiling; Human Protein Atlas; pooled genomic DNA; Pyrosequencing; 454; allelotyping; association studies; bioinformatics; Bioengineering; Bioteknik;

    Sammanfattning : Advancements in the field of biotechnology are expanding the scientific horizon and a promising era is envisioned with personalized medicine for improved health. The amount of genetic data is growing at an ever-escalating pace due to the availability of novel technologies that allow massively parallel sequencing and whole-genome genotyping, that are supported by the advancements in computer science and information technologies. LÄS MER

  7. 5. Genomic divergence in differentially adapted wild and domesticated barley

    Författare :Girma Bedada Chala; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Genomic divergence is responsible for plant differential adaptation to diverse and contrasting environments and different biotic stresses. This thesis focuses on the analyses of the adaptive genomic divergence in wild and domesticated barley and the driving evolutionary forces, and to identify genes and genetic variation with signature of adaptive selection. LÄS MER