Sökning: "predictions in tissue"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden predictions in tissue.

1. 6. Fat-Referenced MRI : Quantitative MRI for Tissue Characterization and Volume Measurement

   Författare :Thobias Romu; Magnus Borga; Olof Dahlqvist Leinhard; Samir Sharma; Linköpings universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MRI; water-fat separation; quantitative MRI;

   Sammanfattning : The amount and distribution of adipose and lean tissues has been shown to be predictive of mortality and morbidity in metabolic disease. Traditionally these risks are assessed by anthropometric measurements based on weight, length, girths or the body mass index (BMI). LÄS MER

3. 7. In vitro and in silico prediction of drug-drug interactions with transport proteins

   Författare :Gustav Ahlin; Per Artursson; Christel Bergström; Johan Karlsson; Jörg König; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; Pharmaceutics; Galenisk farmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics; Biopharmaceutics; biofarmaci;

   Sammanfattning : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. LÄS MER

4. 8. Charcterization of biotransformation systems in human cells

   Författare :Therese Söderdahl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Efforts are continuously being made to improve test procedures so that predictions of toxicity can be made earlier and more accurately. Understanding mechanisms of toxicity is an important part of improving safety assessment, but for this, simplified methods and models to screen for mechanisms associated with toxicity are required. LÄS MER

5. 9. Image Processing, Machine Learning and Visualization for Tissue Analysis

   Författare :Leslie Solorzano; Carolina Wählby; Alexandru Cristian Telea; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Image processing; data analysis; machine learning; visualization; microscopy; Bioinformatics; Bioinformatik;

   Sammanfattning : Knowledge discovery for understanding mechanisms of disease requires the integration of multiple sources of data collected at various magnifications and by different imaging techniques. Using spatial information, we can build maps of tissue and cells in which it is possible to extract, e.g. LÄS MER

7. 10. Robust and Efficient Cell-Based Models of Tissue Mechanics

   Författare :Sonja Mathias; Andreas Hellander; Ruth Baker; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-based model; numerical methods; time integration; adaptivity; GPU acceleration; cell mechanics; embryonic development; cartilage formation; Beräkningsvetenskap; Scientific Computing;

   Sammanfattning : Cell-based models of tissue mechanics have become an important tool in cancer research and developmental biology. Complementary to wet-lab experiments, they allow for cost-efficient in-silico evaluation of mechanisms not easily probed in the lab. LÄS MER