Sökning: "cell-based model"

Visar resultat 1 - 5 av 60 avhandlingar innehållade orden cell-based model.

1. 1. Robust and Efficient Cell-Based Models of Tissue Mechanics

   Författare :Sonja Mathias; Andreas Hellander; Ruth Baker; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-based model; numerical methods; time integration; adaptivity; GPU acceleration; cell mechanics; embryonic development; cartilage formation; Beräkningsvetenskap; Scientific Computing;

   Sammanfattning : Cell-based models of tissue mechanics have become an important tool in cancer research and developmental biology. Complementary to wet-lab experiments, they allow for cost-efficient in-silico evaluation of mechanisms not easily probed in the lab. LÄS MER

3. 2. Strategies to optimize T cell-based cancer immunotherapy

   Författare :Simona Vertuani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MHC class 1; CTL; DNA vaccine; HER-2; Retinoic acid;

   Sammanfattning : Remarkable progress has been made in the field of tumor immunology in the past decade but active immunotherapy is not yet an established treatment modality. Tumor associated antigens (TAAs) presented in the form of peptides in association with MHC class 1 can be recognized by T cells and represent major targets of immunotherapy strategies to treat cancer patients. LÄS MER

4. 3. Cell-based models for studying paediatric high-grade gliomas

   Författare :Susanna Larsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; paediatric brain tumour; glioblastoma; glioma stem cell; primary culture; xenograft tumour; zebrafish;

   Sammanfattning : Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one of the most devastating forms with very poor prognosis due to lack of efficient treatments. LÄS MER

5. 4. Stem cell-based models to study cellular alterations in Parkinson’s Disease

   Författare :Margarita Chumarina; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; stem cells; IPSCs; dopaminergic neurons; oligodendrocytes; omics;

   Sammanfattning : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. LÄS MER

7. 5. Dynamic shaping of human NK cell receptor repertoires : implications for NK cell-based immunotherapy

   Författare :Lisa Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Natural killer (NK) cells are innate lymphocytes with a potent intrinsic capacity to kill tumor cells, which makes them attractive candidates for cell-based cancer immunotherapy. Advances during the past decade have revealed that NK cells display a high degree of functional plasticity, suggesting that some subsets may be more effective in targeting cancer cells. LÄS MER