Sökning: "polyethylene glycol PEG"

Visar resultat 16 - 20 av 54 avhandlingar innehållade orden polyethylene glycol PEG.

  1. 16. Intestinal preservation for transplantation: translational approaches

    Författare :John M. Söfteland; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal transplantation; intestinal preservation; apoptosis; tight junction; luminal preservation;

    Sammanfattning : Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental evidence suggests that combining vascular perfusion and cold storage with luminal interventions using polyethylene glycol (PEG) solutions may mitigate the mucosal damage and extend the safe storage time. LÄS MER

  3. 17. Drug Eluting Hydrogels : Design, Synthesis and Evaluation

    Författare :Lage Ahrenstedt; Deon Bezuidenhout; Michael Malkoch; University of Cape Town; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drug delivery; PEGylation; Rapamycin; Dexamethasone; Controlled release; Hydrogels; Slow release;

    Sammanfattning : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. LÄS MER

  4. 18. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers

    Författare :Malin Morin Zetterberg; Katarina Edwards; Jonas Bergquist; Ana Maria Carmona-Ribeiro; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; model membranes; drug delivery; drug partitioning; antimicrobial peptides; nanocarriers; cryo-TEM; polymer-stabilized bilayer disks; Chemistry with specialization in Physical Chemistry; Kemi med inriktning mot fysikalisk kemi;

    Sammanfattning : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. LÄS MER

  5. 19. Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions

    Författare :Per Wessman; Katarina Edwards; Martin Malmsten; Michel Lafleur; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : The main focus of this thesis is on the effects caused by α-helical peptides on liposome structure, the impact of cholesterol on the peptide-membrane interactions, and the effect of aggregate curvature on the peptide affinity. Results of the studies show that the membrane destabilizing effect of the cationic α-helical peptide melittin is modulated by cholesterol. LÄS MER

  7. 20. Colloidal interactions and arrested dynamics of cellulose nanofibrils

    Författare :Malin Nordenström; Lars Wågberg; Torbjörn Pettersson; Lars Göran Ödberg; Andreas Fall; Wim Thielemans; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cellulose nanofibrils; colloidal interactions; colloidal stability; arrested state; colloidal glass; colloidal gel; tracer diffusion; counterion; steric stabilization; redispersion; redispersion agent; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : Over the past decades, concerns for the environment have increased and efforts to achieve a sustainable society have intensified. One particular challenge is to replace fossil-based plastics with biodegradable materials produced from renewable resources. LÄS MER