Sökning: "oligomeric"

Visar resultat 11 - 15 av 140 avhandlingar innehållade ordet oligomeric.

1. 11. Early events in disease associated protein misfolding

   Författare :Sofie Nyström; Per Hammarström; Marcus Fändrich; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

   Sammanfattning : The scope of this thesis is to unravel some of the mysteries concerning events takingplace early in the amyloid cascade. In vitro studies of early misfolded states ofamyloidogenic proteins are important since the use of recombinant proteins allow us to monitor slight changes in environmental conditions as well as in amino acid composition and thereby illuminate the problem at near atomic resolution. LÄS MER

3. 12. Soluble amyloid-β aggregates in Alzheimer’s disease

   Författare :Hillevi Englund; Frida Ekholm Pettersson; Lars NG Nilsson; Lars Lannfelt; Dominic M Walsh; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Geriatrics; geriatrik;

   Sammanfattning : Soluble oligomeric aggregates of the amyloid-β (Aβ) peptide are suggested to initiate Alzheimer's disease (AD), leading to impaired synapse signalling, widespread neuronal death and loss of cognitive functions. These aggregates seem tightly linked to disease progression, and have therefore gained much attention as potential novel disease markers. LÄS MER

4. 13. Mucins in normal and diseased airways

   Författare :Hans Hovenberg; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Respiratory system; Submucosal glands; Goblet cells; Organ culture; Respiratory tract; Mucins; Mucus glycoproteins; Andningsorganen;

   Sammanfattning : Mucus glycoproteins (mucins) are the principal constituents of respiratory secretions in health and disease. The increased 'acidity' of mucin producing cells in the bronchitic airways is not reflected in a change of negative charge of bronchitic mucins. LÄS MER

5. 14. The Alzheimer Aβ Peptide : Identification of Properties Distinctive for Toxic Prefibrillar Species

   Författare :Anna-Lena Göransson; Jenny Presto; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Proteins must have specific conformations to function correctly inside cells. However, sometimes they adopt the wrong conformation, causing dysfunction and disease. A number of amyloid diseases are caused by misfolded proteins that form amyloid fibrils. One such disease is Alzheimer’s disease (AD). LÄS MER

7. 15. The Design and Structure Prediction of Protein Oligomers

   Författare :Robert Lizatovic; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

   Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER