Sökning: "neurofilament proteins"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden neurofilament proteins.

  1. 6. Prediction value of genetic and neuromarkers in blood and liquor in patients with severe traumatic brain injury

    Författare :Martin Öst; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; outcome; NFL; GFAP; tau; β-amyloid; apolipoprotein E; biochemical neuromarkers;

    Sammanfattning : Background: Severe traumatic brain injury (sTBI) is the most common cause of mortality in young adults. sTBI induces variable brain damage, invisible in Computer Tomographic scans early post-trauma. Further, neurology is difficult to evaluate in sedated patients. LÄS MER

  3. 7. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

    Författare :Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. LÄS MER

  4. 8. Structural and functional alterations in the rat retina after long term exposure to two n-hexane metabolites

    Författare :Birgitta Bäckström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :n-Hexane; 2; 5-hexanedione; 2; 5-hexanediol; immunohistochemical techniques; neurotoxicity; retinopathy; photoreceptors; light energy; electrophysiology; pupil;

    Sammanfattning : Exposure to the two n-hexane metabolites, 2,5-hexanedione (2,5-HD) and 2,5-hexanediol (2,5-HDol) causes swellings in the distal part of long nerve axons. This phenomenon, centralperipheral distal axonopathy, was studied using an indirect immuno-peroxidase method with monoclonal antibodies to neurofilament protein. LÄS MER

  5. 9. Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects

    Författare :Michael Jonsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; white matter changes; vascular factors; cognitive impairment; neuropsychiatric symptoms; cerebrospinal fluid biomarkers; demyelination; axonal degeneration;

    Sammanfattning : Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical constituents of WMC are only partially known. LÄS MER

  7. 10. The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression

    Författare :Victor Karlström; Neus Visa; Ayelet Lamm; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; Alternative splicing; miRNA processing; neuronal differentiaton; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals. LÄS MER