Sökning: "multi-domain"

Visar resultat 31 - 35 av 46 avhandlingar innehållade ordet multi-domain.

  1. 31. Development of a Yeast Model for Functional Analysis of Human Copper Transport Proteins

    Författare :Kumaravel Ponnandai Schanmugavel; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; luminal loop; metal binding domains; Wilson’s disease protein; yeast model; ATP7B; copper transport.;

    Sammanfattning : ABSTRACT Copper (Cu) is an important trace element that plays a vital role in several biological processes. It mediates numerous biochemical functions to maintain cellular homeostasis making it an essential metal for sustaining life. LÄS MER

  3. 32. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

    Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

    Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER

  4. 33. Cryo-electron tomography of individual protein molecules

    Författare :Sara Sandin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cryo-Electron Microscopy; Cryo-Electron Tomography; Protein Conformation; Antibodies; Immunoglobulin G; Glucocorticoid Receptor; Hepatocyte Growth Factor Scatter Factor; Receptor Tyrosine Kinase MET;

    Sammanfattning : Averaging methods of determining structure, such as X-ray diffraction, do not preserve information about the flexibility of molecules. Cryo-electron tomography allows us to reconstruct individual hydrated objects. LÄS MER

  5. 34. The character of magnetic records of deformed soft sediments with emphasis on liquefaction structures

    Författare :Guangyu Sun; Nils Axel Mörner; Don Tarling; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; magnetism; sediments; deformation; Earth sciences; Geovetenskap;

    Sammanfattning : In this thesis the characteristics of magnetic records in deformed soft sediments during postglacial time in Sweden are studied. Magnetic records refer in this study to magnetic remanence (NRM and ChRM) and susceptibility, including its anisotropy (AMS). LÄS MER

  7. 35. Functional studies of Escherichia coli stringent response factor RelA

    Författare :Ievgen Dzhygyr; Vasili Hauryliuk; Jörgen Johansson; Greg Bokinsky; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stringent response; RelA; p ppGpp; ribosome; tRNA; metabolism regulation; allosteric regulation; translation; nutritional stress; molekylärbiologi; Molecular Biology;

    Sammanfattning : RelA is a ribosome associated multi-domain enzyme, which plays a crucial role in adaptation ofEscherichia coli to nutritional stress as such as amino acid deficiency. It detects the deficiency of aminoacids in the cell by monitoring whether a tRNA at the acceptor site (A-site) of the ribosome is chargedwith amino acid or not. LÄS MER