Sökning: "Vicky Shingler"

Hittade 2 avhandlingar innehållade orden Vicky Shingler.

1. 1. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

   Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

   Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER

3. 2. Metabolism-dependent taxis and control of motility in Pseudomonas putida

   Författare :Sofia Österberg; Vicky Shingler; Caroline Harwood; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Motility; c-di-GMP; metabolism-dependent taxis; receptors; transcription; Pseudomonas putida; molekylärbiologi; Molecular Biology;

   Sammanfattning : Bacteria living in soil and aquatic habitats rapidly adapt to changes in physico-chemical parameters that influence their energy status and thus their ability to proliferate and survive. One immediate survival strategy is to relocate to more metabolically optimal environments. LÄS MER