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Visar resultat 11 - 15 av 46 avhandlingar som matchar ovanstående sökkriterier.

1. 11. Protein disulfide isomerase : function and mechanism in oxidative protein folding

   Författare :Ruoyu Xiao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Protein disulfide isomerase; endoplasmic reticulum; protein folding;

   Sammanfattning : The formation of native intramolecular disulfide bonds is critical for the folding and stability of many secreted proteins. This process involves oxidation of protein thiols to form disulfide bonds as well as rearrangement of any non-native disulfide bonds that might form. LÄS MER

3. 12. Exploring the Role of the PDZ Domain in a Supramodule

   Författare :Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. LÄS MER

4. 13. Dementia diagnostics in primary care : with a focus on cognitive testing

   Författare :Anna Segernäs Kvitting; Jan Marcusson; Mats Foldevi; Anders Wimo; Hans Basun; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : BackgroundAge is the greatest risk factor for developing dementia and the total number of people aged 60 years and above is expected to more than double globally from 2013 to 2050 (1). Primary health care (PHC) is important for basic diagnostic evaluations. LÄS MER

5. 14. Spark Plasma Sintering Enhancing Grain Sliding, Deformation and Grain Size Control : Studies of the Systems Ti, Ti/TiB2, Na0.5 K0.5 NbO3, and Hydroxyapatite

   Författare :Mirva Eriksson; Zhijian Shen; Takashi Goto; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spark plasma sintering; plastic deformation; grain growth; titanium; TiB2; hydroxyapatite; Na0.5K0.5NbO3; ferroelectric; transparent; Materials chemistry; Materialkemi; Materials Chemistry; materialkemi;

   Sammanfattning : The unique features of the Spark plasma sintering (SPS) were used to investigate the sintering and deformation behaviour of titanium and titanium–titanium diboride composites, and to control the sintering and grain growth of ferroelectric Na0.5K0.5NbO3 (NKN) and of hydroxyapatite (HAp). LÄS MER

7. 15. The relationship between orthology, protein domain architecture and protein function

   Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER