Sökning: "mucus layer"

Visar resultat 21 - 25 av 45 avhandlingar innehållade orden mucus layer.

  1. 21. Assembly and proteolytic cleavages of gel-forming mucins

    Författare :Martin Lidell; Göteborgs universitet; []
    Nyckelord :mucins; MUC2; MUC5AC; dimer; trimer; cleavage; Entamoeba histolytica; cysteine protease;

    Sammanfattning : Gel-forming mucins are large glycoproteins constituting the main structural component of themucus layer protecting epithelial surfaces of the body. This thesis aims to a deeper understandingof how gel-forming mucins are synthesized and assembled, and how they may interact with othermolecules. LÄS MER

  3. 22. Molecular associations and transport properties of amphiphiles and gastrointestinal mucin in aqueous solution

    Författare :Géraldine Lafitte; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; transport properties; diffusion NMR; Magnetic resonance imaging; Physical chemistry; hydrophobic association; electrostatic repulsion; gel; Mucin; Surfactant;

    Sammanfattning : An effective uptake/absorption of drug formulations involve many processes; one being the transport of the active molecule through the mucus layer. The mucus layer is a complex mixture of biological molecules. Among them, mucin is the molecule that mainly provides the gel properties of the layer. LÄS MER

  4. 23. Characterization of secreted Giardia intestinalis cysteine proteases

    Författare :Jingyi Liu; Staffan G Svärd; Lars Hellman; Andre Buret; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Giardia intestinalis; ESPs; CPs; apical junction; chemokines; phage display; immunoglobulins; defensins; mucin.; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Giardia intestinalis, the causative agent of the diarrheal disease giardiasis, is a protozoan parasite that colonizes the upper small intestine of mammals, including humans. It can be divided into eight genotypes or assemblages (A through H) and only assemblage A and B are infective to humans. LÄS MER

  5. 24. Diet and inflammation : the role of nitrate and conjugated linoleic acid

    Författare :Cecilia Jädert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A diet rich in vegetables and unsaturated fatty acids is associated with a lower risk of major diseases including cardiovascular disease, type 2 diabetes and chronic inflammation. Yet, despite extensive research, the active component(s) responsible for these effects has not been pinpointed and studies with single nutrients have been largely unsuccessful. LÄS MER

  7. 25. DissolvIt : development and validation of a new in vitro dissolution apparatus for dry powder aerosols

    Författare :Maria Malmlöf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Today there are no recommended dissolution methods for use in the development of new inhalable drugs. In the absence of such tailored methods, standard dissolution test methods from oral- or skin administration routes are used instead. Such methods are obviously not designed to resemble the lung environment. LÄS MER