Sökning: "mouse olfactory system"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden mouse olfactory system.

  1. 6. Molecular and functional anatomy of the mouse olfactory epithelium

    Författare :Viktoria Vedin; Anna Berghard; Urban Lendahl; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; olfactory epithelium; odorant receptor; zone; odorant; gene expression; cell specification; c-Fos; dichlobenil; olfactometry; proliferation; Molecular biology; Molekylärbiologi;

    Sammanfattning : The olfactory system is important for social behaviors, feeding and avoiding predators. Detection of odorous molecules is made by odorant receptors on specialized sensory neurons in the olfactory epithelial sheet. LÄS MER

  3. 7. Activity-regulated retinoic acid signaling in olfactory sensory neurons

    Författare :Hande Login; Staffan Bohm; Mattias Alenius; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse olfactory system; RA; neuronal activity; CNG; Cyp26B1; BACE1; Kirrel-2; molekylärbiologi; Molecular Biology;

    Sammanfattning : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. LÄS MER

  4. 8. Neurotropic influenza A virus infection in the mouse brain : targeting, persistence and functional effects

    Författare :Fredrik Aronsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Influenza A virus; nervous system;

    Sammanfattning : Viral infections of the central nervous system have been associated with sensory, motor and behavioral disturbances both in humans and in animals. An example of this is influenza A virus infection that causes acute respiratory diseases, which occasionally are followed by complications from the central nervous system. LÄS MER

  5. 9. Investigating the function of Anaplastic Lymphoma Kinase

    Författare :Emma Vernersson Lindahl; Bengt Hallberg; Ruth Palmer; Göran Roos; Carina Hellberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALK; nervous system; knockout; development; Jelly-Belly; Pathology; Patologi;

    Sammanfattning : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. LÄS MER

  7. 10. Expression of cathelicidin antimicrobial peptides in man and rat

    Författare :Stefan Termén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :LL-37; rCRAMP; butyrate; colonic epithelium; central nervous system; transcription;

    Sammanfattning : Endogenous antimicrobial peptides are effectors of innate immunity. They kill microorganisms by disrupting their cell membranes, but are also believed to have signaling functions in the immune system. They are present in epithelia, secretions and phagocytic cells. LÄS MER