Sökning: "mouse olfactory system"

Visar resultat 16 - 20 av 22 avhandlingar innehållade orden mouse olfactory system.

1. 16. Neural circuit mapping af orexigenic systems

   Författare :Iris Stoltenborg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orexigenic; ghrelin; feeding; food-cue; arcuate nucleus; lateral hypothalamus; orexin; activity-based anorexia;

   Sammanfattning : Orexigenic systems in the brain process appetite and/or hunger information and ultimately coordinate feeding responses. These brain circuits are critical for survival and originally evolved to ensure that we consume sufficient amounts of diverse nutrients to survive future famines. LÄS MER

3. 17. Non-motor symptoms in Parkinson’s disease : modeling and mechanisms

   Författare :Débora Masini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson’s disease (PD) is a common neurodegenerative disorder, typically characterized by the progressive death of midbrain dopaminergic neurons projecting from the substantia nigra to other areas within the basal ganglia. Historically, PD has been diagnosed as a purely motor disorder dominated by bradykinesia (slowness of movement), rigidity, resting tremor, and postural instability. LÄS MER

4. 18. Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease

   Författare :Ming Zhao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Parkinson s disease; substantia nigra pars compacta; adult neurogenesis; stereology; apoptosis; dopamine; tyrosine hydroxylase; nestin; 5-bromodeoxyuridine; [3H]-thymidine; MPTP; 6-OHDA; platelet-derived growth factor-BB;

   Sammanfattning : The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods used for detecting newborn nerve cells in adult brain regions with a low rate of neurogenesis; to explore the mechanism of nerve cell death in animal models of parkinsonism and early degenerative and restorative changes in nigral cell populations; and to develop a therapeutic approach that could translate into a future restorative disease-modifying strategy in PD. Paper I. LÄS MER

5. 19. Transcriptome-wide analysis in cells and tissues

   Författare :Sanja Vickovic; Afshin Ahmadian; Itai Yanai; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA-sequencing; single cells; spatially resolved transcriptomics; 3D profiling.; Biotechnology; Bioteknologi;

   Sammanfattning : High-throughput sequencing has greatly influenced the amount of data produced and biological questions asked and answered. Sequencing approaches have also enabled rapid development of related technological fields such as single-cell and spatially resolved expression profiling. LÄS MER

7. 20. Progressive models of Parkinson's disease : behavioural and neurochemical analyses

   Författare :Alexandra Alvarsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson’s disease (PD) is a common neurodegenerative disorder diagnosed based on the presence of motor symptoms, including resting tremor, postural impairment, bradykinesia and rigidity. The pathological hallmarks are degeneration of midbrain dopaminergic neurons and the accumulation of inclusions containing the misfolded protein α-synuclein (termed “Lewy bodies”) throughout the nervous system. LÄS MER